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- W2324585754 abstract "Various types of acetylcholine (ACh) receptor in the pleural or abdominal ganglion cells of Aplysia were classified into three types depending on the ion species involved in the electrogenesis of their responses.The Na-dependent receptor was designated the DNa-type since the response was a depolarization (D) produced by an increase in permeability, mainly toward Na+, although other ions were partially involved.Similarly, the Cl- or K-dependent receptor was designated the HCl- or HK-type since the response was a hyperpolarization (H) produced by an exclusive increase in permeability toward Cl- or K+.AChinduced responses were evaluated by an increase in membrane conductance.The DNa-type receptor could be readily activated by tetramethylammonium (TMA) and choline, but not by decamethonium (Deca).Instead, it was blocked competitively either by hexamethonium (Hexa) or by Deca.The HCl-type receptor could be readily activated by TMA, choline, and Deca.Hexa did not block this type of receptor.The HK-type receptor was neither activated nor blocked by TMA, choline, Hexa, and Deca.The above findings suggested that there is a certain structural similarityin the ACh-binding site between DNa-type and HCl-type receptors, although the ion species involved in the electrogenesis of each responsewere totally different.The structure of the ACh-binding site at theHK-type receptor seemed considerably different from that of eitherDNa-type or HCl-type." @default.
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- W2324585754 date "1980-01-01" @default.
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- W2324585754 title "Effects of onium derivatives on Na-, Cl-, and K-dependent acetylcholine receptors." @default.
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- W2324585754 doi "https://doi.org/10.2170/jjphysiol.30.729" @default.
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