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• W2324593391 abstract "La leucémie à tricholeucocytes est un syndrome lymphoprolifératif de phénotype B rare. Elle survient habituellement chez les hommes de plus de 50 ans. Jusqu'en 1984, les moyens thérapeutiques étaient très décevants et la plupart des patients décédaient des complications liées à la cytopénie. L'introduction de l'interféron et plus récemment des analogues des bases puriques (pentostatine et 2-chlorodéoxyadénosine) a transformé le pronostic de cette affection. Néanmoins, si des rémissions complètes sont quelquefois obtenues par l'interféron et de façon plus fréquente grâce aux analogues des bases puriques, aucun de ces traitements ne semble faire disparaître complètement les tricholeucocytes. Il convient donc de traiter ces patients souvent âgés en fonction des effets secondaires de ces médicaments et de leurs bénéfices attendus.Hairy cell leukemia is a rare lymphoproliferative B disorder. It usually occurs in men older than 50 years. Until 1984, therapeutic approaches had been disappointing and most of the patients died from complications of cytopenia. The introduction of Interferon and, more recently of purine analogues (pentostatin and 2-chlorodeoxyadenosine) improved outcome of this disease. Nevertheless, if complete remissions may be achieved sometimes with Interferon and more frequently with purine analogues, none of these treatments seems able to remove hairy cells. So, therapeutic decision has to be made according to the efficacy and the potential adverse effects of these drugs." @default.
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• W2324593391 date "1987-03-01" @default.
• W2324593391 modified "2023-09-30" @default.
• W2324593391 title "La leucémie à tricholeucocytes. Données thérapeutiques actuelles sur l'interféron" @default.
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• W2324593391 doi "https://doi.org/10.1016/s0248-8663(87)80170-4" @default.
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