FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2324650642> ?p ?o ?g. }

• W2324650642 endingPage "A824" @default.
• W2324650642 startingPage "A823.3" @default.
• W2324650642 abstract "<h3>Background</h3> The association between antiphospholipid antibodies (aPL) and thrombophilic state in antiphospholipid syndrome (APS) is well recognized^[1], but the underlying pathophysiology remains incompletely elucidated. Several findings suggest the role of complement system (CS) in the pathogenesis of antiphospholipid syndrome (APS)^[2]. The importance of CS in APS is understandable since complement-derived inflammatory mediators increase vascular permeability, activate platelets and promote release of cytokines from monocytesthat favor systemic inflammation and coagulation^[3]. It has been demonstrated in a mouse model of aPL-induced pregnancy loss that complement activation can amplify the fetal injury^[4,5]. CS activation has been also documented in patients with APS^[6], but there are far fewer clinical data. <h3>Objectives</h3> To evaluate the relation between CS and coagulation cascade in APS. <h3>Methods</h3> We used plasma samples from healthy women [H] (pregnant: n=5; non pregnant: n=5) and from patients with APS who were non pregnant (n=6), pregnant (n=10), in catastrophic phase [CAT] (n=4) or in a quiescent phase but with the same autoantibody profile of CAT (triple positivity for lupus anticoagulant, anticardiolipin and anti β2-glycoptrotein I antibodies) [SPECIAL] (n=4). The levels of activated complement components (C5a and C5b-9) and Tissue factor (TF) were analyzed using specific ELISA assays. <h3>Results</h3> During this preliminary study, main differences on C5a plasma levels were observed between H and patients with APS (mean H non pregnant: 4.28; APS non pregnant: 10.52), especially in subjects during CAT and in SPECIAL ones (mean 17.38 and 20.49, respectively). No marked differences were observed between pregnant H and with APS (mean APS: 7.97, H: 7.96). Similar data were obtained form C5b-9 analysis. Plasma TF values in samples from the same women described before were investigated. Among the two subgroups of H women, we didn’t observed significant differences in TF values. Conversely, we found interesting differences between non pregnant H controls and patients with APS (mean H: 88.46; APS: 212.21). High values were also documented in APS patients with CAT despite the anticoagulant treatment (mean 168.51), while lower TF values had been observed in pregnant women with APS and in SPECIAL ones (mean 138.17 and 104.65, respectively). We point out that pregnant women with APS and SPECIAL ones received anticoagulant drug to prevent the thrombi formation. <h3>Conclusions</h3> These preliminary data, together with other already reported, support the hypothesis of an involvement of CS in the modulation of coagulation activity in APS, especially in patients with triple positivity. <h3>References</h3> de Groot PG et al. <i>Curr Opin Hematol</i> 2004;11:165-9. Oku K et al. <i>Ann Rheum Dis</i>. 2009;68:1030-5. Cavazzana I et al. <i>J Autoimmun</i> 2007;28:160-164. Girardi G et al. <i>J Clin Invest</i> 2003;112:1644-54. Holers VM et al. <i>J Exp Med</i> 2002;1995:211-20. Lim W. <i>Curr Opin Hemat</i> 2011;18:361-365. <h3>Disclosure of Interest</h3> None Declared" @default.
• W2324650642 created "2016-06-24" @default.
• W2324650642 creator A5006667947 @default.
• W2324650642 creator A5011458062 @default.
• W2324650642 creator A5011919997 @default.
• W2324650642 creator A5025372587 @default.
• W2324650642 creator A5033735578 @default.
• W2324650642 creator A5081414451 @default.
• W2324650642 creator A5085761102 @default.
• W2324650642 date "2013-06-01" @default.
• W2324650642 modified "2023-09-25" @default.
• W2324650642 title "AB0125 The crosstalk between the complement system and the coagulation cascade in the antiphospholipid syndrome. preliminary data from basic research." @default.
• W2324650642 doi "https://doi.org/10.1136/annrheumdis-2013-eular.2448" @default.
• W2324650642 hasPublicationYear "2013" @default.
• W2324650642 type Work @default.
• W2324650642 sameAs 2324650642 @default.
• W2324650642 citedByCount "0" @default.
• W2324650642 crossrefType "journal-article" @default.
• W2324650642 hasAuthorship W2324650642A5006667947 @default.
• W2324650642 hasAuthorship W2324650642A5011458062 @default.
• W2324650642 hasAuthorship W2324650642A5011919997 @default.
• W2324650642 hasAuthorship W2324650642A5025372587 @default.
• W2324650642 hasAuthorship W2324650642A5033735578 @default.
• W2324650642 hasAuthorship W2324650642A5081414451 @default.
• W2324650642 hasAuthorship W2324650642A5085761102 @default.
• W2324650642 hasConcept C111684460 @default.
• W2324650642 hasConcept C126322002 @default.
• W2324650642 hasConcept C159654299 @default.
• W2324650642 hasConcept C163764329 @default.
• W2324650642 hasConcept C203014093 @default.
• W2324650642 hasConcept C2776874634 @default.
• W2324650642 hasConcept C2776914184 @default.
• W2324650642 hasConcept C2780022809 @default.
• W2324650642 hasConcept C2780942790 @default.
• W2324650642 hasConcept C71924100 @default.
• W2324650642 hasConcept C79196540 @default.
• W2324650642 hasConceptScore W2324650642C111684460 @default.
• W2324650642 hasConceptScore W2324650642C126322002 @default.
• W2324650642 hasConceptScore W2324650642C159654299 @default.
• W2324650642 hasConceptScore W2324650642C163764329 @default.
• W2324650642 hasConceptScore W2324650642C203014093 @default.
• W2324650642 hasConceptScore W2324650642C2776874634 @default.
• W2324650642 hasConceptScore W2324650642C2776914184 @default.
• W2324650642 hasConceptScore W2324650642C2780022809 @default.
• W2324650642 hasConceptScore W2324650642C2780942790 @default.
• W2324650642 hasConceptScore W2324650642C71924100 @default.
• W2324650642 hasConceptScore W2324650642C79196540 @default.
• W2324650642 hasIssue "Suppl 3" @default.
• W2324650642 hasLocation W23246506421 @default.
• W2324650642 hasOpenAccess W2324650642 @default.
• W2324650642 hasPrimaryLocation W23246506421 @default.
• W2324650642 hasRelatedWork W165669756 @default.
• W2324650642 hasRelatedWork W1977645254 @default.
• W2324650642 hasRelatedWork W2019511528 @default.
• W2324650642 hasRelatedWork W2022289753 @default.
• W2324650642 hasRelatedWork W2069553539 @default.
• W2324650642 hasRelatedWork W2074986892 @default.
• W2324650642 hasRelatedWork W2099792460 @default.
• W2324650642 hasRelatedWork W2156299866 @default.
• W2324650642 hasRelatedWork W2319931263 @default.
• W2324650642 hasRelatedWork W2502283878 @default.
• W2324650642 hasVolume "72" @default.
• W2324650642 isParatext "false" @default.
• W2324650642 isRetracted "false" @default.
• W2324650642 magId "2324650642" @default.
• W2324650642 workType "article" @default.