Matches in SemOpenAlex for { <https://semopenalex.org/work/W2324664764> ?p ?o ?g. }
Showing items 1 to 73 of
73
with 100 items per page.
- W2324664764 endingPage "122" @default.
- W2324664764 startingPage "116" @default.
- W2324664764 abstract "The effect of the dosage of methotrexate (MTX) on pharmacokinetic parameters in renal, hepatic and hematological functions were investigated. Twenty osteosarcoma patients (age: 13-53 years) received MTX infusions (dosage: 3.3-11.2g/m2) for 6 hrs. The serum MTX concentrations at 6h, 12h and 24h increased almost proportionally with the infused dose. The total serum MTX clearance and half-lives were almost constant in all the dosing ranges examined.To evaluate the relationship between the dosage and laboratory values, the patients were divided into three groups based on the MTX dosage and consisting of: low-dose (dosage: 3.3-5.2g/m2), middle-dose (dosage: 5.4-8.3g/m2), and high-dose (dosage: 9.0-11.2g/m2) groups. There was no significant difference between the renal and hematological functions before MTX infusion. In the high-dose group, significantly increased GOT and GPT values were observed on days 2 and 7, which indicate a decreased in hepatic function.In spite of the linear pharmacokinetics of MIX, a high-dose may cause remarkably nonlinear increased GOT and GPT values compared to those with low-and middle-doses.To avoid a severe adverse reaction of MTX therapy in the high-dosage group, careful monitoring of both the serum concentration of MTX and the liver functions is considered to be important after infusion." @default.
- W2324664764 created "2016-06-24" @default.
- W2324664764 creator A5000192888 @default.
- W2324664764 creator A5004963629 @default.
- W2324664764 creator A5016610821 @default.
- W2324664764 creator A5016885437 @default.
- W2324664764 creator A5031236297 @default.
- W2324664764 creator A5037470884 @default.
- W2324664764 creator A5050611344 @default.
- W2324664764 creator A5063902603 @default.
- W2324664764 creator A5082752747 @default.
- W2324664764 date "2000-01-01" @default.
- W2324664764 modified "2023-09-28" @default.
- W2324664764 title "Pharmacokinetics and Adverse Reaction in Methotrexate Therapy of Osteosarcoma." @default.
- W2324664764 doi "https://doi.org/10.5649/jjphcs1975.26.116" @default.
- W2324664764 hasPublicationYear "2000" @default.
- W2324664764 type Work @default.
- W2324664764 sameAs 2324664764 @default.
- W2324664764 citedByCount "2" @default.
- W2324664764 crossrefType "journal-article" @default.
- W2324664764 hasAuthorship W2324664764A5000192888 @default.
- W2324664764 hasAuthorship W2324664764A5004963629 @default.
- W2324664764 hasAuthorship W2324664764A5016610821 @default.
- W2324664764 hasAuthorship W2324664764A5016885437 @default.
- W2324664764 hasAuthorship W2324664764A5031236297 @default.
- W2324664764 hasAuthorship W2324664764A5037470884 @default.
- W2324664764 hasAuthorship W2324664764A5050611344 @default.
- W2324664764 hasAuthorship W2324664764A5063902603 @default.
- W2324664764 hasAuthorship W2324664764A5082752747 @default.
- W2324664764 hasBestOaLocation W23246647641 @default.
- W2324664764 hasConcept C112705442 @default.
- W2324664764 hasConcept C126322002 @default.
- W2324664764 hasConcept C126894567 @default.
- W2324664764 hasConcept C159641895 @default.
- W2324664764 hasConcept C197934379 @default.
- W2324664764 hasConcept C2777288759 @default.
- W2324664764 hasConcept C2781059491 @default.
- W2324664764 hasConcept C71924100 @default.
- W2324664764 hasConcept C77281830 @default.
- W2324664764 hasConcept C90924648 @default.
- W2324664764 hasConcept C98274493 @default.
- W2324664764 hasConceptScore W2324664764C112705442 @default.
- W2324664764 hasConceptScore W2324664764C126322002 @default.
- W2324664764 hasConceptScore W2324664764C126894567 @default.
- W2324664764 hasConceptScore W2324664764C159641895 @default.
- W2324664764 hasConceptScore W2324664764C197934379 @default.
- W2324664764 hasConceptScore W2324664764C2777288759 @default.
- W2324664764 hasConceptScore W2324664764C2781059491 @default.
- W2324664764 hasConceptScore W2324664764C71924100 @default.
- W2324664764 hasConceptScore W2324664764C77281830 @default.
- W2324664764 hasConceptScore W2324664764C90924648 @default.
- W2324664764 hasConceptScore W2324664764C98274493 @default.
- W2324664764 hasIssue "1" @default.
- W2324664764 hasLocation W23246647641 @default.
- W2324664764 hasOpenAccess W2324664764 @default.
- W2324664764 hasPrimaryLocation W23246647641 @default.
- W2324664764 hasRelatedWork W1995894256 @default.
- W2324664764 hasRelatedWork W2004325424 @default.
- W2324664764 hasRelatedWork W2013875815 @default.
- W2324664764 hasRelatedWork W2041599956 @default.
- W2324664764 hasRelatedWork W2051764329 @default.
- W2324664764 hasRelatedWork W2054007511 @default.
- W2324664764 hasRelatedWork W2080969318 @default.
- W2324664764 hasRelatedWork W2084265116 @default.
- W2324664764 hasRelatedWork W2616641857 @default.
- W2324664764 hasRelatedWork W2793520024 @default.
- W2324664764 hasVolume "26" @default.
- W2324664764 isParatext "false" @default.
- W2324664764 isRetracted "false" @default.
- W2324664764 magId "2324664764" @default.
- W2324664764 workType "article" @default.