FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2324704013> ?p ?o ?g. }

• W2324704013 abstract "Event Abstract Back to Event BET bromodomain inhibition by JQ1 suppresses interleukin-6 secretion in myeloma cells Rohit R. Ghurye1*, Helen J. Stewart1 and Timothy J. Chevassut1 1 Brighton and Sussex Medical School, United Kingdom Background: Multiple myeloma (MM) is a malignant and progressive tumour of plasma cells. Overproduction of interleukin-6 (IL-6), a pleiotropic cytokine, is believed to play an important role in the pathogenesis of MM. Consequently, research has focused on targeting IL-6 as a therapeutic strategy for MM. Bromodomains are a diverse family of protein interaction modules that have a vital role in transcriptional regulation. Recent studies using well-established models of inflammation have shown that inhibitors of the bromodomain and extraterminal (BET) family of proteins suppress the expression of several pro-inflammatory cytokines including IL-6. The aim of this study is to investigate the effect of JQ1, a small molecule bromodomain inhibitor, on human MM cells and IL-6 secretion. Methods: Primary MM cells were isolated from venous blood of a patient with refractory MM. To explore the effect on IL-6 secretion, primary MM cells were pre-treated with various concentrations of JQ1 then stimulated with lipopolysaccharide (LPS) and an IL-6 ELISA was performed. The effect on cell viability was measured using the WST-1 assay. Results: Pre-treatment of LPS stimulated primary MM cells with JQ1 led to a dose-dependent suppression of IL-6 secretion. In addition, JQ1 exposure caused a time-dependent decrease in primary MM cell viability. Conclusion: Treatment with JQ1 is not only cytotoxic to primary MM cells but also suppresses secretion of IL-6. These findings suggest that bromodomain inhibitors such as JQ1 represent a promising new class of immunomodulatory compounds that are highly active against MM. Acknowledgements We would like to thank Professor Knapp (Structural Genome Consortium, University of Oxford) for kindly donating the bromodomain inhibitor, JQ1. References 1. Lauta VM. Interleukin-6 and the network of several cytokines in multiple myeloma: an overview of clinical and experimental data. Cytokine (2001) 16: 79-86. 2. Nicodeme E, Jeffrey KL, Schaefer U, Beinke S, Dewell S, Chung CW, Chandwani R, Marazzi I, Wilson P, Coste H, White J, Kirilovsky J, Rice CM, Lora JM, Prinjha RK, Lee K, Tarakhovsky A. Suppression of inflammation by a synthetic histone mimic. Nature (2010) 468: 1119-23. Keywords: Interleukin-6, BET Family, Bromodomain inhibitor, JQ1, Multiple Myeloma Conference: 15th International Congress of Immunology (ICI), Milan, Italy, 22 Aug - 27 Aug, 2013. Presentation Type: Abstract Topic: Translational immunology and immune intervention Citation: Ghurye RR, Stewart HJ and Chevassut TJ (2013). BET bromodomain inhibition by JQ1 suppresses interleukin-6 secretion in myeloma cells. Front. Immunol. Conference Abstract: 15th International Congress of Immunology (ICI). doi: 10.3389/conf.fimmu.2013.02.00823 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 19 Jun 2013; Published Online: 22 Aug 2013. * Correspondence: Dr. Rohit R Ghurye, Brighton and Sussex Medical School, Brighton, BN1 9PS, United Kingdom, rohitghurye@doctors.org.uk Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Rohit R Ghurye Helen J Stewart Timothy J Chevassut Google Rohit R Ghurye Helen J Stewart Timothy J Chevassut Google Scholar Rohit R Ghurye Helen J Stewart Timothy J Chevassut PubMed Rohit R Ghurye Helen J Stewart Timothy J Chevassut Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page." @default.
• W2324704013 created "2016-06-24" @default.
• W2324704013 creator A5010164134 @default.
• W2324704013 creator A5028910394 @default.
• W2324704013 creator A5067253368 @default.
• W2324704013 date "2013-01-01" @default.
• W2324704013 modified "2023-09-25" @default.
• W2324704013 title "BET bromodomain inhibition by JQ1 suppresses interleukin-6 secretion in myeloma cells" @default.
• W2324704013 doi "https://doi.org/10.3389/conf.fimmu.2013.02.00823" @default.
• W2324704013 hasPublicationYear "2013" @default.
• W2324704013 type Work @default.
• W2324704013 sameAs 2324704013 @default.
• W2324704013 citedByCount "0" @default.
• W2324704013 crossrefType "journal-article" @default.
• W2324704013 hasAuthorship W2324704013A5010164134 @default.
• W2324704013 hasAuthorship W2324704013A5028910394 @default.
• W2324704013 hasAuthorship W2324704013A5067253368 @default.
• W2324704013 hasBestOaLocation W23247040131 @default.
• W2324704013 hasConcept C104317684 @default.
• W2324704013 hasConcept C126322002 @default.
• W2324704013 hasConcept C1491633281 @default.
• W2324704013 hasConcept C185592680 @default.
• W2324704013 hasConcept C203014093 @default.
• W2324704013 hasConcept C2107291 @default.
• W2324704013 hasConcept C2776364478 @default.
• W2324704013 hasConcept C2776914184 @default.
• W2324704013 hasConcept C2778690821 @default.
• W2324704013 hasConcept C41091548 @default.
• W2324704013 hasConcept C49039625 @default.
• W2324704013 hasConcept C502942594 @default.
• W2324704013 hasConcept C53227056 @default.
• W2324704013 hasConcept C55493867 @default.
• W2324704013 hasConcept C71924100 @default.
• W2324704013 hasConcept C74172505 @default.
• W2324704013 hasConcept C74401373 @default.
• W2324704013 hasConcept C86803240 @default.
• W2324704013 hasConcept C95444343 @default.
• W2324704013 hasConceptScore W2324704013C104317684 @default.
• W2324704013 hasConceptScore W2324704013C126322002 @default.
• W2324704013 hasConceptScore W2324704013C1491633281 @default.
• W2324704013 hasConceptScore W2324704013C185592680 @default.
• W2324704013 hasConceptScore W2324704013C203014093 @default.
• W2324704013 hasConceptScore W2324704013C2107291 @default.
• W2324704013 hasConceptScore W2324704013C2776364478 @default.
• W2324704013 hasConceptScore W2324704013C2776914184 @default.
• W2324704013 hasConceptScore W2324704013C2778690821 @default.
• W2324704013 hasConceptScore W2324704013C41091548 @default.
• W2324704013 hasConceptScore W2324704013C49039625 @default.
• W2324704013 hasConceptScore W2324704013C502942594 @default.
• W2324704013 hasConceptScore W2324704013C53227056 @default.
• W2324704013 hasConceptScore W2324704013C55493867 @default.
• W2324704013 hasConceptScore W2324704013C71924100 @default.
• W2324704013 hasConceptScore W2324704013C74172505 @default.
• W2324704013 hasConceptScore W2324704013C74401373 @default.
• W2324704013 hasConceptScore W2324704013C86803240 @default.
• W2324704013 hasConceptScore W2324704013C95444343 @default.
• W2324704013 hasLocation W23247040131 @default.
• W2324704013 hasOpenAccess W2324704013 @default.
• W2324704013 hasPrimaryLocation W23247040131 @default.
• W2324704013 hasRelatedWork W132959013 @default.
• W2324704013 hasRelatedWork W1969512070 @default.
• W2324704013 hasRelatedWork W1982930427 @default.
• W2324704013 hasRelatedWork W2089747020 @default.
• W2324704013 hasRelatedWork W2169628503 @default.
• W2324704013 hasRelatedWork W2240106681 @default.
• W2324704013 hasRelatedWork W2329114789 @default.
• W2324704013 hasRelatedWork W4296670012 @default.
• W2324704013 hasRelatedWork W4322154645 @default.
• W2324704013 hasRelatedWork W639339275 @default.
• W2324704013 hasVolume "4" @default.
• W2324704013 isParatext "false" @default.
• W2324704013 isRetracted "false" @default.
• W2324704013 magId "2324704013" @default.
• W2324704013 workType "article" @default.