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- W2324713041 abstract "From vinyl sulfonamides as precursors to vinyl sulfonamide epoxides, two cascade reaction protocols were developed to synthesize eight-membered ring sultams in water. These protocols employ intermolecular Michael addition by NaOH or NaHS in water, followed by rapid proton transfer and intramolecular 8-endo-tet epoxide ring-opening to give medium-size sultams selectively in one-pot. Novel core structures and high synthetic efficiency make these cascade reactions highly suitable for sultam library production. Both reactions proceeded well and afforded the respective sultams in good yields under environmentally friendly conditions." @default.
- W2324713041 created "2016-06-24" @default.
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- W2324713041 date "2013-11-13" @default.
- W2324713041 modified "2023-10-02" @default.
- W2324713041 title "Parallel Syntheses of Eight-Membered Ring Sultams via Two Cascade Reactions in Water" @default.
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- W2324713041 doi "https://doi.org/10.1021/co400116p" @default.
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