Matches in SemOpenAlex for { <https://semopenalex.org/work/W2324772015> ?p ?o ?g. }
Showing items 1 to 68 of
68
with 100 items per page.
- W2324772015 endingPage "198" @default.
- W2324772015 startingPage "188" @default.
- W2324772015 abstract "3D-QSAR has become a very important tool in the field of Drug Discovery, especially in important areas like malarial research. The 3D-QSAR is principally a ligand-based drug design but the bioactive conformation of the ligand can also be taken into account in constructing a 3D-QSAR model. The induction of receptor-based 3D-QSAR has been proven to give more robust statistical models. In this review, we have discussed the various 3D-QSAR works done so far which were aimed at combating malaria caused by Plasmodium falciparam. We have also discussed the various enzymes/receptors (targets) in Plasmodium falciparam for which the 3D-QSAR had been generated. The enzymes - wild and mutated dihydrofolate reductase, enoyl acyl protein carrier protein reductase, farnesyltransferase, cytochrome bc1, and falcipains were the major targets for pharmacophore-based drug design. Apart from the above-mentioned targets there were many scaffolds for which the target macromolecule was undefined and could have single/multiple targets. The generated 3D-QSAR model can be used to identify hits by screening the pharmacophore against a chemical library. In this review, the hits identified against various targets of plasmodium falciparam that have been discussed along with their basic scaffold. The various software programs and chemical databases that have been used in the generation of 3D-QSAR and screening were given. From this review, we understand that there is a considerable need to develop novel scaffolds that are different from the existing ligands to overcome cross-resistance." @default.
- W2324772015 created "2016-06-24" @default.
- W2324772015 creator A5028525685 @default.
- W2324772015 creator A5035823087 @default.
- W2324772015 date "2015-02-15" @default.
- W2324772015 modified "2023-09-27" @default.
- W2324772015 title "3D-QSAR Studies on Plasmodium falciparam Proteins: A Mini-Review" @default.
- W2324772015 doi "https://doi.org/10.2174/1386207318666141229124747" @default.
- W2324772015 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25543683" @default.
- W2324772015 hasPublicationYear "2015" @default.
- W2324772015 type Work @default.
- W2324772015 sameAs 2324772015 @default.
- W2324772015 citedByCount "7" @default.
- W2324772015 countsByYear W23247720152017 @default.
- W2324772015 countsByYear W23247720152019 @default.
- W2324772015 countsByYear W23247720152021 @default.
- W2324772015 countsByYear W23247720152022 @default.
- W2324772015 crossrefType "journal-article" @default.
- W2324772015 hasAuthorship W2324772015A5028525685 @default.
- W2324772015 hasAuthorship W2324772015A5035823087 @default.
- W2324772015 hasConcept C119857082 @default.
- W2324772015 hasConcept C164126121 @default.
- W2324772015 hasConcept C181199279 @default.
- W2324772015 hasConcept C185592680 @default.
- W2324772015 hasConcept C2781320022 @default.
- W2324772015 hasConcept C41008148 @default.
- W2324772015 hasConcept C55493867 @default.
- W2324772015 hasConcept C56173144 @default.
- W2324772015 hasConcept C60644358 @default.
- W2324772015 hasConcept C70721500 @default.
- W2324772015 hasConcept C71240020 @default.
- W2324772015 hasConcept C74187038 @default.
- W2324772015 hasConcept C86803240 @default.
- W2324772015 hasConceptScore W2324772015C119857082 @default.
- W2324772015 hasConceptScore W2324772015C164126121 @default.
- W2324772015 hasConceptScore W2324772015C181199279 @default.
- W2324772015 hasConceptScore W2324772015C185592680 @default.
- W2324772015 hasConceptScore W2324772015C2781320022 @default.
- W2324772015 hasConceptScore W2324772015C41008148 @default.
- W2324772015 hasConceptScore W2324772015C55493867 @default.
- W2324772015 hasConceptScore W2324772015C56173144 @default.
- W2324772015 hasConceptScore W2324772015C60644358 @default.
- W2324772015 hasConceptScore W2324772015C70721500 @default.
- W2324772015 hasConceptScore W2324772015C71240020 @default.
- W2324772015 hasConceptScore W2324772015C74187038 @default.
- W2324772015 hasConceptScore W2324772015C86803240 @default.
- W2324772015 hasIssue "2" @default.
- W2324772015 hasLocation W23247720151 @default.
- W2324772015 hasLocation W23247720152 @default.
- W2324772015 hasOpenAccess W2324772015 @default.
- W2324772015 hasPrimaryLocation W23247720151 @default.
- W2324772015 hasRelatedWork W1515081291 @default.
- W2324772015 hasRelatedWork W1996293670 @default.
- W2324772015 hasRelatedWork W2000960205 @default.
- W2324772015 hasRelatedWork W2004397427 @default.
- W2324772015 hasRelatedWork W2018607294 @default.
- W2324772015 hasRelatedWork W2044041242 @default.
- W2324772015 hasRelatedWork W2049221459 @default.
- W2324772015 hasRelatedWork W2164452133 @default.
- W2324772015 hasRelatedWork W2950171690 @default.
- W2324772015 hasRelatedWork W3122701998 @default.
- W2324772015 hasVolume "18" @default.
- W2324772015 isParatext "false" @default.
- W2324772015 isRetracted "false" @default.
- W2324772015 magId "2324772015" @default.
- W2324772015 workType "article" @default.