Matches in SemOpenAlex for { <https://semopenalex.org/work/W2324785043> ?p ?o ?g. }
- W2324785043 abstract "Escherichia colicauses three types of illnesses in humans: diarrhea, urinary tract infections, and meningitis in newborns. The acquisition of virulence-associated genes and the ability to properly regulate these, often horizontally transferred, loci distinguishes pathogens from the normally harmless commensal E. coli found within the human intestine. This review addresses our current understanding of virulence gene regulation in several important diarrhea-causing pathotypes, including enteropathogenic, enterohemorrhagic,enterotoxigenic, and enteroaggregativeE. coli-EPEC, EHEC, ETEC and EAEC, respectively. The intensely studied regulatory circuitry controlling virulence of uropathogenicE. coli, or UPEC, is also reviewed, as is that of MNEC, a common cause of meningitis in neonates. Specific topics covered include the regulation of initial attachment events necessary for infection, environmental cues affecting virulence gene expression, control of attaching and effacing lesionformation, and control of effector molecule expression and secretion via the type III secretion systems by EPEC and EHEC. How phage control virulence and the expression of the Stx toxins of EHEC, phase variation, quorum sensing, and posttranscriptional regulation of virulence determinants are also addressed. A number of important virulence regulators are described, including the AraC-like molecules PerA of EPEC, CfaR and Rns of ETEC, and AggR of EAEC;the Ler protein of EPEC and EHEC;RfaH of UPEC;and the H-NS molecule that acts to silence gene expression. The regulatory circuitry controlling virulence of these greatly varied E. colipathotypes is complex, but common themes offerinsight into the signals and regulators necessary forE. coli disease progression." @default.
- W2324785043 created "2016-06-24" @default.
- W2324785043 creator A5052345153 @default.
- W2324785043 creator A5059760414 @default.
- W2324785043 date "2006-10-12" @default.
- W2324785043 modified "2023-09-24" @default.
- W2324785043 title "Virulence Gene Regulation in <i>Escherichia coli</i>" @default.
- W2324785043 cites W10051111 @default.
- W2324785043 cites W121997899 @default.
- W2324785043 cites W1425706641 @default.
- W2324785043 cites W1484631462 @default.
- W2324785043 cites W1492527967 @default.
- W2324785043 cites W1497416668 @default.
- W2324785043 cites W1499426843 @default.
- W2324785043 cites W1520297488 @default.
- W2324785043 cites W1531895406 @default.
- W2324785043 cites W1536997383 @default.
- W2324785043 cites W1538795905 @default.
- W2324785043 cites W1539475140 @default.
- W2324785043 cites W1549143748 @default.
- W2324785043 cites W1554203136 @default.
- W2324785043 cites W1569617625 @default.
- W2324785043 cites W1577720361 @default.
- W2324785043 cites W1593385374 @default.
- W2324785043 cites W1727598810 @default.
- W2324785043 cites W17388179 @default.
- W2324785043 cites W1740971377 @default.
- W2324785043 cites W1831336687 @default.
- W2324785043 cites W1848279380 @default.
- W2324785043 cites W1857929448 @default.
- W2324785043 cites W1860449000 @default.
- W2324785043 cites W1868993240 @default.
- W2324785043 cites W1875741656 @default.
- W2324785043 cites W1901154529 @default.
- W2324785043 cites W1903574298 @default.
- W2324785043 cites W1904593082 @default.
- W2324785043 cites W1907928115 @default.
- W2324785043 cites W1914363360 @default.
- W2324785043 cites W1915267559 @default.
- W2324785043 cites W1916428098 @default.
- W2324785043 cites W1918492382 @default.
- W2324785043 cites W1933232990 @default.
- W2324785043 cites W1942835246 @default.
- W2324785043 cites W1953090660 @default.
- W2324785043 cites W1953201941 @default.
- W2324785043 cites W1954076903 @default.
- W2324785043 cites W1961727790 @default.
- W2324785043 cites W1964096332 @default.
- W2324785043 cites W1965117944 @default.
- W2324785043 cites W1965943918 @default.
- W2324785043 cites W1966597734 @default.
- W2324785043 cites W1967384112 @default.
- W2324785043 cites W1967865250 @default.
- W2324785043 cites W1969431491 @default.
- W2324785043 cites W1969963017 @default.
- W2324785043 cites W1970257633 @default.
- W2324785043 cites W1972435034 @default.
- W2324785043 cites W1973274802 @default.
- W2324785043 cites W1973578316 @default.
- W2324785043 cites W1979615338 @default.
- W2324785043 cites W1980659148 @default.
- W2324785043 cites W1981469078 @default.
- W2324785043 cites W1981626175 @default.
- W2324785043 cites W1982201679 @default.
- W2324785043 cites W1982282046 @default.
- W2324785043 cites W1982836127 @default.
- W2324785043 cites W1984581511 @default.
- W2324785043 cites W1985396638 @default.
- W2324785043 cites W1986147894 @default.
- W2324785043 cites W1986340051 @default.
- W2324785043 cites W1987452421 @default.
- W2324785043 cites W1988771590 @default.
- W2324785043 cites W1991673019 @default.
- W2324785043 cites W1993036666 @default.
- W2324785043 cites W1993414798 @default.
- W2324785043 cites W1994462493 @default.
- W2324785043 cites W1995727060 @default.
- W2324785043 cites W1996135784 @default.
- W2324785043 cites W1996795202 @default.
- W2324785043 cites W1997810660 @default.
- W2324785043 cites W1999027251 @default.
- W2324785043 cites W1999823179 @default.
- W2324785043 cites W1999997395 @default.
- W2324785043 cites W2000282637 @default.
- W2324785043 cites W2001320805 @default.
- W2324785043 cites W2002645780 @default.
- W2324785043 cites W2003046928 @default.
- W2324785043 cites W2003729219 @default.
- W2324785043 cites W2004643319 @default.
- W2324785043 cites W2005473844 @default.
- W2324785043 cites W2005874007 @default.
- W2324785043 cites W2007921389 @default.
- W2324785043 cites W2008649826 @default.
- W2324785043 cites W2008752222 @default.
- W2324785043 cites W2008931521 @default.
- W2324785043 cites W2010041726 @default.
- W2324785043 cites W2011581454 @default.
- W2324785043 cites W2011687683 @default.
- W2324785043 cites W2012341274 @default.
- W2324785043 cites W2014035470 @default.