Matches in SemOpenAlex for { <https://semopenalex.org/work/W2324809448> ?p ?o ?g. }
- W2324809448 endingPage "480" @default.
- W2324809448 startingPage "472" @default.
- W2324809448 abstract "Knowledge about the profile of neutralization responses and the viral envelope features of HIV-1-infected individuals in China may provide new insights for vaccine design against local viruses.Eight hundred sixty plasma samples from antiretroviral treatment-naive HIV-1-infected individuals in Xinjiang province (611) and Guangxi province (249), who had acquired infection over 3 years through intravenous drug use or sexual contact, were examined for their ability to neutralize diverse envelope-pseudoviruses of 5 subtypes. The sequence features of the envelopes from elite neutralizers were analyzed.From Xinjiang and Guangxi, 29.1% and 5.2% of plasmas displayed intrasubtype cross neutralization against subtype B and subtype C, respectively. From Xinjiang, 10.6% of the plasmas displayed broad neutralization against the 3 subtypes, B, C, and CRF01_AE; whereas only 2.4% from Guangxi displayed broad neutralization. Envelopes from 6 elite neutralizers were obtained by single-genome amplification. The variations of their envelopes including the lengths, glycans, and net charges in V1, V2, and V4 regions were compared with those from CRF07_BC env sequences from the HIV Sequence Database. The Envs from 3 elite neutralizers displayed the sensitivities to the monoclonal broadly neutralizing antibodies such as PG9, PG16, and 4E10. Some unique characteristics of the envelope glycoproteins from the Chinese elite neutralizers were found.The neutralization profile of HIV-1-infected individuals in the 2 regions of China, where the HIV-1 subtypes are the representative in China, and the unique characteristics of the envelope glycoproteins from the Chinese elite neutralizers provide useful information for viral infection prevention and an insight for vaccine design against locally epidemic viruses." @default.
- W2324809448 created "2016-06-24" @default.
- W2324809448 creator A5001955185 @default.
- W2324809448 creator A5008175753 @default.
- W2324809448 creator A5014295844 @default.
- W2324809448 creator A5015723806 @default.
- W2324809448 creator A5024814904 @default.
- W2324809448 creator A5046887099 @default.
- W2324809448 creator A5059266311 @default.
- W2324809448 creator A5070122813 @default.
- W2324809448 creator A5070671167 @default.
- W2324809448 creator A5076397659 @default.
- W2324809448 creator A5081987477 @default.
- W2324809448 creator A5089647526 @default.
- W2324809448 creator A5089852302 @default.
- W2324809448 date "2014-12-15" @default.
- W2324809448 modified "2023-09-27" @default.
- W2324809448 title "Cross-Neutralizing Antibody Profile of Chinese HIV-1-Infected Individuals and the Viral Envelope Features From Elite Neutralizers" @default.
- W2324809448 cites W1503866863 @default.
- W2324809448 cites W1794879226 @default.
- W2324809448 cites W1842798465 @default.
- W2324809448 cites W1965549031 @default.
- W2324809448 cites W1972937369 @default.
- W2324809448 cites W1974290153 @default.
- W2324809448 cites W1978398372 @default.
- W2324809448 cites W1980169905 @default.
- W2324809448 cites W1984658478 @default.
- W2324809448 cites W1990967787 @default.
- W2324809448 cites W1996011751 @default.
- W2324809448 cites W1996907458 @default.
- W2324809448 cites W2002574877 @default.
- W2324809448 cites W2006483986 @default.
- W2324809448 cites W2007760610 @default.
- W2324809448 cites W2009151161 @default.
- W2324809448 cites W2013234834 @default.
- W2324809448 cites W2013330052 @default.
- W2324809448 cites W2016180326 @default.
- W2324809448 cites W2018754025 @default.
- W2324809448 cites W2031604171 @default.
- W2324809448 cites W2034981907 @default.
- W2324809448 cites W2053127269 @default.
- W2324809448 cites W2055841615 @default.
- W2324809448 cites W2056267734 @default.
- W2324809448 cites W2056512147 @default.
- W2324809448 cites W2069955337 @default.
- W2324809448 cites W2076366830 @default.
- W2324809448 cites W2080423713 @default.
- W2324809448 cites W2082241468 @default.
- W2324809448 cites W2083726777 @default.
- W2324809448 cites W2084310667 @default.
- W2324809448 cites W2084363110 @default.
- W2324809448 cites W2094829985 @default.
- W2324809448 cites W2102254707 @default.
- W2324809448 cites W2103712192 @default.
- W2324809448 cites W2109229894 @default.
- W2324809448 cites W2110499527 @default.
- W2324809448 cites W2113236498 @default.
- W2324809448 cites W2118274231 @default.
- W2324809448 cites W2121096721 @default.
- W2324809448 cites W2126887491 @default.
- W2324809448 cites W2132227271 @default.
- W2324809448 cites W2135151522 @default.
- W2324809448 cites W2137939749 @default.
- W2324809448 cites W2146704167 @default.
- W2324809448 cites W2148245437 @default.
- W2324809448 cites W2156012505 @default.
- W2324809448 cites W2158079699 @default.
- W2324809448 cites W2159211452 @default.
- W2324809448 cites W2162528782 @default.
- W2324809448 cites W2177434887 @default.
- W2324809448 cites W4252970270 @default.
- W2324809448 doi "https://doi.org/10.1097/qai.0000000000000345" @default.
- W2324809448 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25202919" @default.
- W2324809448 hasPublicationYear "2014" @default.
- W2324809448 type Work @default.
- W2324809448 sameAs 2324809448 @default.
- W2324809448 citedByCount "4" @default.
- W2324809448 countsByYear W23248094482016 @default.
- W2324809448 countsByYear W23248094482017 @default.
- W2324809448 countsByYear W23248094482020 @default.
- W2324809448 crossrefType "journal-article" @default.
- W2324809448 hasAuthorship W2324809448A5001955185 @default.
- W2324809448 hasAuthorship W2324809448A5008175753 @default.
- W2324809448 hasAuthorship W2324809448A5014295844 @default.
- W2324809448 hasAuthorship W2324809448A5015723806 @default.
- W2324809448 hasAuthorship W2324809448A5024814904 @default.
- W2324809448 hasAuthorship W2324809448A5046887099 @default.
- W2324809448 hasAuthorship W2324809448A5059266311 @default.
- W2324809448 hasAuthorship W2324809448A5070122813 @default.
- W2324809448 hasAuthorship W2324809448A5070671167 @default.
- W2324809448 hasAuthorship W2324809448A5076397659 @default.
- W2324809448 hasAuthorship W2324809448A5081987477 @default.
- W2324809448 hasAuthorship W2324809448A5089647526 @default.
- W2324809448 hasAuthorship W2324809448A5089852302 @default.
- W2324809448 hasConcept C108625454 @default.
- W2324809448 hasConcept C14086860 @default.
- W2324809448 hasConcept C159047783 @default.
- W2324809448 hasConcept C159654299 @default.