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• W2324831444 abstract "The CYP3A5*3 and CYP3A4*1B alleles have been related with tacrolimus (Tac) dose requirements. The rare CYP3A4*22 variant has also been associated with a significantly lower Tac dose. We genotyped the three single-nucleotide polymorphisms in 206 kidney-transplanted patients who received Tac as the primary immunosuppressor. CYP3A5*1 and CYP3A4*1B allele carriers received a significantly higher Tac dose (P<0.01) compared with wild-type homozygotes. We did not find significant differences between the CYP3A4*22 genotypes, either nominally or according to the CYP3A5 genotype (expressers vs. nonexpressers). Sequencing of CYP3A4 coding exons in a total of 15 patients revealed only one nonreported missense change (p.P227>T) in one patient. We concluded that CYP3A5*3 and CYP3A4*1B were the main determinants of the Tac dose-adjusted blood concentration in our cohort of renal-transplanted patients." @default.
• W2324831444 created "2016-06-24" @default.
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• W2324831444 date "2013-08-01" @default.
• W2324831444 modified "2023-10-17" @default.
• W2324831444 title "A search for new CYP3A4 variants as determinants of tacrolimus dose requirements in renal-transplanted patients" @default.
• W2324831444 cites W2011813828 @default.
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• W2324831444 doi "https://doi.org/10.1097/fpc.0b013e3283636856" @default.
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