Matches in SemOpenAlex for { <https://semopenalex.org/work/W2324831610> ?p ?o ?g. }
Showing items 1 to 62 of
62
with 100 items per page.
- W2324831610 abstract "Neuronal replacement therapy—the idea that donor neurons can repair a brain injured by trauma or neurodegenerative disease—continues to attract considerable interest. Such therapy is fraught with challenges, however, because its success requires that donor neurons differentiate and form synaptic connections with appropriate neurons in the host. Czupryn et al . transplanted immature neurons from the hypothalamus of wild-type donor mice into the hypothalamus of mutant mice that were morbidly obese because of a genetic deficiency of the receptor for leptin, a metabolic hormone that signals in the hypothalamus. The donor neurons differentiated into four distinct neuronal types that formed functional synapses, resulting in restoration of hypothalamic leptin signaling and partial reversal of obesity and metabolic defects in the recipient mice. A. Czupryn, Y.-D. Zhou, X. Chen, D. McNay, M. P. Anderson, J. S. Flier, J. D. Macklis, Transplanted hypothalamic neurons restore leptin signaling and ameliorate obesity in db/db mice. Science 334 , 1133–1137 (2011). [Abstract][Full Text]" @default.
- W2324831610 created "2016-06-24" @default.
- W2324831610 creator A5012761292 @default.
- W2324831610 date "2011-11-29" @default.
- W2324831610 modified "2023-09-26" @default.
- W2324831610 title "Applying Brainpower to Obesity" @default.
- W2324831610 doi "https://doi.org/10.1126/scisignal.4201ec333" @default.
- W2324831610 hasPublicationYear "2011" @default.
- W2324831610 type Work @default.
- W2324831610 sameAs 2324831610 @default.
- W2324831610 citedByCount "0" @default.
- W2324831610 crossrefType "journal-article" @default.
- W2324831610 hasAuthorship W2324831610A5012761292 @default.
- W2324831610 hasConcept C126322002 @default.
- W2324831610 hasConcept C134018914 @default.
- W2324831610 hasConcept C14372207 @default.
- W2324831610 hasConcept C169760540 @default.
- W2324831610 hasConcept C170493617 @default.
- W2324831610 hasConcept C2777003273 @default.
- W2324831610 hasConcept C2780613262 @default.
- W2324831610 hasConcept C511355011 @default.
- W2324831610 hasConcept C71315377 @default.
- W2324831610 hasConcept C71924100 @default.
- W2324831610 hasConcept C86803240 @default.
- W2324831610 hasConceptScore W2324831610C126322002 @default.
- W2324831610 hasConceptScore W2324831610C134018914 @default.
- W2324831610 hasConceptScore W2324831610C14372207 @default.
- W2324831610 hasConceptScore W2324831610C169760540 @default.
- W2324831610 hasConceptScore W2324831610C170493617 @default.
- W2324831610 hasConceptScore W2324831610C2777003273 @default.
- W2324831610 hasConceptScore W2324831610C2780613262 @default.
- W2324831610 hasConceptScore W2324831610C511355011 @default.
- W2324831610 hasConceptScore W2324831610C71315377 @default.
- W2324831610 hasConceptScore W2324831610C71924100 @default.
- W2324831610 hasConceptScore W2324831610C86803240 @default.
- W2324831610 hasLocation W23248316101 @default.
- W2324831610 hasOpenAccess W2324831610 @default.
- W2324831610 hasPrimaryLocation W23248316101 @default.
- W2324831610 hasRelatedWork W1555334454 @default.
- W2324831610 hasRelatedWork W1969854375 @default.
- W2324831610 hasRelatedWork W1977473971 @default.
- W2324831610 hasRelatedWork W1977534914 @default.
- W2324831610 hasRelatedWork W1981715740 @default.
- W2324831610 hasRelatedWork W2006832717 @default.
- W2324831610 hasRelatedWork W2015445474 @default.
- W2324831610 hasRelatedWork W2036795994 @default.
- W2324831610 hasRelatedWork W2054438521 @default.
- W2324831610 hasRelatedWork W2064351848 @default.
- W2324831610 hasRelatedWork W2070729834 @default.
- W2324831610 hasRelatedWork W2073325922 @default.
- W2324831610 hasRelatedWork W2105562742 @default.
- W2324831610 hasRelatedWork W2133774373 @default.
- W2324831610 hasRelatedWork W2276488225 @default.
- W2324831610 hasRelatedWork W2279694136 @default.
- W2324831610 hasRelatedWork W2626854720 @default.
- W2324831610 hasRelatedWork W2863119727 @default.
- W2324831610 hasRelatedWork W2896191563 @default.
- W2324831610 hasRelatedWork W2948822335 @default.
- W2324831610 isParatext "false" @default.
- W2324831610 isRetracted "false" @default.
- W2324831610 magId "2324831610" @default.
- W2324831610 workType "article" @default.