Matches in SemOpenAlex for { <https://semopenalex.org/work/W2324842802> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W2324842802 abstract "Abstracts: Frontiers in Cancer Prevention Research 2008B40 Bladder cancer is a complex disease involving multiple genes interacting with each other and/or with environment factors in the tumorigenesis process. We examined 245 SNPs of 22 genes of PI3K-AKT-mTOR pathway which is an essential cellular pathway controlling cell growth, proliferation and survival. We used a case-control design with 803 cases and 803 controls systematically evaluate single nucleotide polymorphisms (SNPs) in this pathway as predicators of bladder cancer risk, in close interaction with environmental factors. In individual SNP analysis, increased bladder cancer risk was significantly associated with 20 SNPs (AKT3: rs12045585, RHEB: rs1920978, RPS6KA5: rs8018757, IRS2: rs9515120, TSC2: rs2073636 and rs8063461, and Raptor: rs11653499, rs9890502, rs8071015, rs7211818, rs9915378, rs9674559, rs7208536, rs7219896, rs4969444, rs2672890, rs7212142, rs9897968, rs2271608, and rs1062935) adjusting by age, gender and smoking status using logistic regression. We grouped the unfavorable SNPs into four categories based on the distribution of the control. Compared to the reference group, the second, third and fourth category showed 1.01 (95%CI: 0.76-1.34), 1.16 (95%CI: 0.89-1.50), and significantly 1.53 (95%CI: 1.14-2.07, P=0.005) fold increased risk of bladder cancer respectively (P for the trend: <0.0001). Classification and regression tree (CART) analysis was performed to explore the high order gene-gene and gene-environment interaction. Further stratification, haplotype and diplotype analysis are still ongoing. This is the first study to address the role of germline genetic variation in this pathway as cancer susceptibility factors. The identification of novel genetic susceptibility markers for bladder cancer etiology will not only help understand the biology of bladder carcinogenesis, but also help identify high risk individuals for bladder cancer. These findings warrant further replication in independent populations.Citation Information: Cancer Prev Res 2008;1(7 Suppl):B40." @default.
- W2324842802 created "2016-06-24" @default.
- W2324842802 creator A5002737792 @default.
- W2324842802 creator A5015664950 @default.
- W2324842802 creator A5020968873 @default.
- W2324842802 creator A5024845093 @default.
- W2324842802 creator A5041358066 @default.
- W2324842802 creator A5066957198 @default.
- W2324842802 creator A5076894669 @default.
- W2324842802 creator A5082365305 @default.
- W2324842802 creator A5088600970 @default.
- W2324842802 date "2008-11-01" @default.
- W2324842802 modified "2023-09-27" @default.
- W2324842802 title "Abstract B40: Genetic variations in PI3K-AKT-mTOR pathway and bladder cancer risk" @default.
- W2324842802 doi "https://doi.org/10.1158/1940-6207.prev-08-b40" @default.
- W2324842802 hasPublicationYear "2008" @default.
- W2324842802 type Work @default.
- W2324842802 sameAs 2324842802 @default.
- W2324842802 citedByCount "0" @default.
- W2324842802 crossrefType "proceedings-article" @default.
- W2324842802 hasAuthorship W2324842802A5002737792 @default.
- W2324842802 hasAuthorship W2324842802A5015664950 @default.
- W2324842802 hasAuthorship W2324842802A5020968873 @default.
- W2324842802 hasAuthorship W2324842802A5024845093 @default.
- W2324842802 hasAuthorship W2324842802A5041358066 @default.
- W2324842802 hasAuthorship W2324842802A5066957198 @default.
- W2324842802 hasAuthorship W2324842802A5076894669 @default.
- W2324842802 hasAuthorship W2324842802A5082365305 @default.
- W2324842802 hasAuthorship W2324842802A5088600970 @default.
- W2324842802 hasConcept C104317684 @default.
- W2324842802 hasConcept C121608353 @default.
- W2324842802 hasConcept C126322002 @default.
- W2324842802 hasConcept C135763542 @default.
- W2324842802 hasConcept C143998085 @default.
- W2324842802 hasConcept C153209595 @default.
- W2324842802 hasConcept C190283241 @default.
- W2324842802 hasConcept C197754878 @default.
- W2324842802 hasConcept C2780352672 @default.
- W2324842802 hasConcept C502942594 @default.
- W2324842802 hasConcept C54355233 @default.
- W2324842802 hasConcept C555283112 @default.
- W2324842802 hasConcept C60644358 @default.
- W2324842802 hasConcept C71924100 @default.
- W2324842802 hasConcept C86554907 @default.
- W2324842802 hasConcept C86803240 @default.
- W2324842802 hasConceptScore W2324842802C104317684 @default.
- W2324842802 hasConceptScore W2324842802C121608353 @default.
- W2324842802 hasConceptScore W2324842802C126322002 @default.
- W2324842802 hasConceptScore W2324842802C135763542 @default.
- W2324842802 hasConceptScore W2324842802C143998085 @default.
- W2324842802 hasConceptScore W2324842802C153209595 @default.
- W2324842802 hasConceptScore W2324842802C190283241 @default.
- W2324842802 hasConceptScore W2324842802C197754878 @default.
- W2324842802 hasConceptScore W2324842802C2780352672 @default.
- W2324842802 hasConceptScore W2324842802C502942594 @default.
- W2324842802 hasConceptScore W2324842802C54355233 @default.
- W2324842802 hasConceptScore W2324842802C555283112 @default.
- W2324842802 hasConceptScore W2324842802C60644358 @default.
- W2324842802 hasConceptScore W2324842802C71924100 @default.
- W2324842802 hasConceptScore W2324842802C86554907 @default.
- W2324842802 hasConceptScore W2324842802C86803240 @default.
- W2324842802 hasLocation W23248428021 @default.
- W2324842802 hasOpenAccess W2324842802 @default.
- W2324842802 hasPrimaryLocation W23248428021 @default.
- W2324842802 hasRelatedWork W1981922135 @default.
- W2324842802 hasRelatedWork W2027526955 @default.
- W2324842802 hasRelatedWork W2067740647 @default.
- W2324842802 hasRelatedWork W2312889472 @default.
- W2324842802 hasRelatedWork W2325914469 @default.
- W2324842802 hasRelatedWork W2332240056 @default.
- W2324842802 hasRelatedWork W2540531639 @default.
- W2324842802 hasRelatedWork W2775411645 @default.
- W2324842802 hasRelatedWork W2782281188 @default.
- W2324842802 hasRelatedWork W2795569133 @default.
- W2324842802 hasRelatedWork W2890448276 @default.
- W2324842802 hasRelatedWork W2983904742 @default.
- W2324842802 hasRelatedWork W3009906634 @default.
- W2324842802 hasRelatedWork W3024706420 @default.
- W2324842802 hasRelatedWork W3038129077 @default.
- W2324842802 hasRelatedWork W3044255220 @default.
- W2324842802 hasRelatedWork W3107634544 @default.
- W2324842802 hasRelatedWork W3113336709 @default.
- W2324842802 hasRelatedWork W3142765789 @default.
- W2324842802 hasRelatedWork W3187073325 @default.
- W2324842802 isParatext "false" @default.
- W2324842802 isRetracted "false" @default.
- W2324842802 magId "2324842802" @default.
- W2324842802 workType "article" @default.