FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2324889009> ?p ?o ?g. }

• W2324889009 endingPage "5939" @default.
• W2324889009 startingPage "5936" @default.
• W2324889009 abstract "Abstract The macrocyclization of linear peptides is very often accompanied by significant improvements in their stability and biological activity. Many strategies are available for their chemical macrocyclization, however, enzyme‐mediated methods remain of great interest in terms of synthetic utility. To date, known macrocyclization enzymes have been shown to be active on both peptide and protein substrates. Here we show that the macrocyclization enzyme of the cyanobactin family, PatGmac, is capable of macrocyclizing substrates with one, two, or three 1,4‐substituted 1,2,3‐triazole moieties. The introduction of non‐peptidic scaffolds into macrocycles is highly desirable in tuning the activity and physical properties of peptidic macrocycles. We have isolated and fully characterized nine non‐natural triazole‐containing cyclic peptides, a further ten molecules are also synthesized. PatGmac has now been shown to be an effective and versatile tool for the ring closure by peptide bond formation." @default.
• W2324889009 created "2016-06-24" @default.
• W2324889009 creator A5017202324 @default.
• W2324889009 creator A5028467044 @default.
• W2324889009 creator A5029773529 @default.
• W2324889009 creator A5051490485 @default.
• W2324889009 date "2016-04-05" @default.
• W2324889009 modified "2023-10-12" @default.
• W2324889009 title "Enzymatic Macrocyclization of 1,2,3-Triazole Peptide Mimetics" @default.
• W2324889009 cites W1955057702 @default.
• W2324889009 cites W1968652549 @default.
• W2324889009 cites W1976254260 @default.
• W2324889009 cites W1976941763 @default.
• W2324889009 cites W1997014543 @default.
• W2324889009 cites W2012340394 @default.
• W2324889009 cites W2014246127 @default.
• W2324889009 cites W2023018411 @default.
• W2324889009 cites W2023557482 @default.
• W2324889009 cites W2041593863 @default.
• W2324889009 cites W2054798478 @default.
• W2324889009 cites W2061174398 @default.
• W2324889009 cites W2077498510 @default.
• W2324889009 cites W2092894994 @default.
• W2324889009 cites W2100390260 @default.
• W2324889009 cites W2101187401 @default.
• W2324889009 cites W2105387254 @default.
• W2324889009 cites W2109877846 @default.
• W2324889009 cites W2113450820 @default.
• W2324889009 cites W2114064167 @default.
• W2324889009 cites W2121976982 @default.
• W2324889009 cites W2143678800 @default.
• W2324889009 cites W2162481919 @default.
• W2324889009 cites W2191442969 @default.
• W2324889009 cites W2267190811 @default.
• W2324889009 cites W2314613702 @default.
• W2324889009 cites W2950192043 @default.
• W2324889009 cites W2951385014 @default.
• W2324889009 doi "https://doi.org/10.1002/ange.201601564" @default.
• W2324889009 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4924597" @default.
• W2324889009 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27397939" @default.
• W2324889009 hasPublicationYear "2016" @default.
• W2324889009 type Work @default.
• W2324889009 sameAs 2324889009 @default.
• W2324889009 citedByCount "33" @default.
• W2324889009 countsByYear W23248890092016 @default.
• W2324889009 countsByYear W23248890092017 @default.
• W2324889009 countsByYear W23248890092018 @default.
• W2324889009 countsByYear W23248890092019 @default.
• W2324889009 countsByYear W23248890092020 @default.
• W2324889009 countsByYear W23248890092021 @default.
• W2324889009 countsByYear W23248890092022 @default.
• W2324889009 countsByYear W23248890092023 @default.
• W2324889009 crossrefType "journal-article" @default.
• W2324889009 hasAuthorship W2324889009A5017202324 @default.
• W2324889009 hasAuthorship W2324889009A5028467044 @default.
• W2324889009 hasAuthorship W2324889009A5029773529 @default.
• W2324889009 hasAuthorship W2324889009A5051490485 @default.
• W2324889009 hasBestOaLocation W23248890091 @default.
• W2324889009 hasConcept C178790620 @default.
• W2324889009 hasConcept C181199279 @default.
• W2324889009 hasConcept C185592680 @default.
• W2324889009 hasConcept C202751555 @default.
• W2324889009 hasConcept C21951064 @default.
• W2324889009 hasConcept C2777907353 @default.
• W2324889009 hasConcept C2779281246 @default.
• W2324889009 hasConcept C2780378348 @default.
• W2324889009 hasConcept C2991874392 @default.
• W2324889009 hasConcept C32909587 @default.
• W2324889009 hasConcept C55493867 @default.
• W2324889009 hasConcept C60984968 @default.
• W2324889009 hasConcept C69610077 @default.
• W2324889009 hasConcept C71240020 @default.
• W2324889009 hasConceptScore W2324889009C178790620 @default.
• W2324889009 hasConceptScore W2324889009C181199279 @default.
• W2324889009 hasConceptScore W2324889009C185592680 @default.
• W2324889009 hasConceptScore W2324889009C202751555 @default.
• W2324889009 hasConceptScore W2324889009C21951064 @default.
• W2324889009 hasConceptScore W2324889009C2777907353 @default.
• W2324889009 hasConceptScore W2324889009C2779281246 @default.
• W2324889009 hasConceptScore W2324889009C2780378348 @default.
• W2324889009 hasConceptScore W2324889009C2991874392 @default.
• W2324889009 hasConceptScore W2324889009C32909587 @default.
• W2324889009 hasConceptScore W2324889009C55493867 @default.
• W2324889009 hasConceptScore W2324889009C60984968 @default.
• W2324889009 hasConceptScore W2324889009C69610077 @default.
• W2324889009 hasConceptScore W2324889009C71240020 @default.
• W2324889009 hasFunder F4320334678 @default.
• W2324889009 hasIssue "19" @default.
• W2324889009 hasLocation W23248890091 @default.
• W2324889009 hasLocation W23248890092 @default.
• W2324889009 hasLocation W23248890093 @default.
• W2324889009 hasLocation W23248890094 @default.
• W2324889009 hasLocation W23248890095 @default.
• W2324889009 hasLocation W23248890096 @default.
• W2324889009 hasLocation W23248890097 @default.
• W2324889009 hasOpenAccess W2324889009 @default.
• W2324889009 hasPrimaryLocation W23248890091 @default.
• W2324889009 hasRelatedWork W1976620854 @default.

• next