FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2324894503> ?p ?o ?g. }

• W2324894503 endingPage "565a" @default.
• W2324894503 startingPage "565a" @default.
• W2324894503 abstract "The bacterial mechanosensitive channel MscL is constituted of homopentamer of a subunit with two transmembrane inner and outer (TM1, TM2) α-helices, and its 3D structure of the closed state has been resolved. The major issue of MscL is to understand the gating mechanism driven by tension in the membrane. To address this question, molecular dynamics (MD) studies have been performed, however, as they do not include MscL-lipid interactions, it remains unclear which amino acids sense membrane tension and how the sensed force induces channel opening. Thus we performed MD simulations for the opening of MscL embedded in the lipid bilayer. Among amino acids in TM2 facing the bilayer, Phe78 showed exceptionally strong interaction with lipids. Upon membrane stretch, Phe78 was dragged by lipids, leading to an opening of MscL. Thus Phe78 was concluded to be the major tension sensor. Neighboring TM1s cross and interact with each other near the cytoplasmic side through hydrophobic interaction between Leu19-Val23 in one TM1 and Gly22 in the neighboring TM1, forming the most constricted hydrophobic part of the pore called gate. Upon membrane stretch, the helices are dragged by lipids at Phe78 and tilted, accompanied by the outward sliding of the crossings, leading to expanding of the gate. In this study, we newly modeled the Eco-MscL with the N-terminal (S1) helices running parallel to the cytoplasmic membrane instead of forming the tight bundle proposed previously and determined the role of the S1 helices in channel opening. As a result, the newly modeled MscL opened faster than the previous one. Furthermore, some amino acids in the S1 interact with lipids rigidly, suggesting that the S1 acts as a mechanosensor to transmit force for accelerating the gate opening." @default.
• W2324894503 created "2016-06-24" @default.
• W2324894503 creator A5031274171 @default.
• W2324894503 creator A5064068441 @default.
• W2324894503 date "2015-01-01" @default.
• W2324894503 modified "2023-09-26" @default.
• W2324894503 title "The N-Terminal Domain of Bacterial Mechanosensitive MscL Acts as a Mechanosensor: Molecular Dynamics Study" @default.
• W2324894503 doi "https://doi.org/10.1016/j.bpj.2014.11.3092" @default.
• W2324894503 hasPublicationYear "2015" @default.
• W2324894503 type Work @default.
• W2324894503 sameAs 2324894503 @default.
• W2324894503 citedByCount "0" @default.
• W2324894503 crossrefType "journal-article" @default.
• W2324894503 hasAuthorship W2324894503A5031274171 @default.
• W2324894503 hasAuthorship W2324894503A5064068441 @default.
• W2324894503 hasBestOaLocation W23248945031 @default.
• W2324894503 hasConcept C112950240 @default.
• W2324894503 hasConcept C118892022 @default.
• W2324894503 hasConcept C12554922 @default.
• W2324894503 hasConcept C147597530 @default.
• W2324894503 hasConcept C170493617 @default.
• W2324894503 hasConcept C185592680 @default.
• W2324894503 hasConcept C186068551 @default.
• W2324894503 hasConcept C18903297 @default.
• W2324894503 hasConcept C190062978 @default.
• W2324894503 hasConcept C191897082 @default.
• W2324894503 hasConcept C192157962 @default.
• W2324894503 hasConcept C192562407 @default.
• W2324894503 hasConcept C194544171 @default.
• W2324894503 hasConcept C203087120 @default.
• W2324894503 hasConcept C24530287 @default.
• W2324894503 hasConcept C2778530040 @default.
• W2324894503 hasConcept C2779965526 @default.
• W2324894503 hasConcept C39944091 @default.
• W2324894503 hasConcept C4001165 @default.
• W2324894503 hasConcept C41625074 @default.
• W2324894503 hasConcept C47701112 @default.
• W2324894503 hasConcept C50254741 @default.
• W2324894503 hasConcept C515207424 @default.
• W2324894503 hasConcept C55493867 @default.
• W2324894503 hasConcept C59593255 @default.
• W2324894503 hasConcept C8010536 @default.
• W2324894503 hasConcept C86803240 @default.
• W2324894503 hasConceptScore W2324894503C112950240 @default.
• W2324894503 hasConceptScore W2324894503C118892022 @default.
• W2324894503 hasConceptScore W2324894503C12554922 @default.
• W2324894503 hasConceptScore W2324894503C147597530 @default.
• W2324894503 hasConceptScore W2324894503C170493617 @default.
• W2324894503 hasConceptScore W2324894503C185592680 @default.
• W2324894503 hasConceptScore W2324894503C186068551 @default.
• W2324894503 hasConceptScore W2324894503C18903297 @default.
• W2324894503 hasConceptScore W2324894503C190062978 @default.
• W2324894503 hasConceptScore W2324894503C191897082 @default.
• W2324894503 hasConceptScore W2324894503C192157962 @default.
• W2324894503 hasConceptScore W2324894503C192562407 @default.
• W2324894503 hasConceptScore W2324894503C194544171 @default.
• W2324894503 hasConceptScore W2324894503C203087120 @default.
• W2324894503 hasConceptScore W2324894503C24530287 @default.
• W2324894503 hasConceptScore W2324894503C2778530040 @default.
• W2324894503 hasConceptScore W2324894503C2779965526 @default.
• W2324894503 hasConceptScore W2324894503C39944091 @default.
• W2324894503 hasConceptScore W2324894503C4001165 @default.
• W2324894503 hasConceptScore W2324894503C41625074 @default.
• W2324894503 hasConceptScore W2324894503C47701112 @default.
• W2324894503 hasConceptScore W2324894503C50254741 @default.
• W2324894503 hasConceptScore W2324894503C515207424 @default.
• W2324894503 hasConceptScore W2324894503C55493867 @default.
• W2324894503 hasConceptScore W2324894503C59593255 @default.
• W2324894503 hasConceptScore W2324894503C8010536 @default.
• W2324894503 hasConceptScore W2324894503C86803240 @default.
• W2324894503 hasIssue "2" @default.
• W2324894503 hasLocation W23248945031 @default.
• W2324894503 hasOpenAccess W2324894503 @default.
• W2324894503 hasPrimaryLocation W23248945031 @default.
• W2324894503 hasRelatedWork W1843075121 @default.
• W2324894503 hasRelatedWork W1968380264 @default.
• W2324894503 hasRelatedWork W1969565316 @default.
• W2324894503 hasRelatedWork W1982283179 @default.
• W2324894503 hasRelatedWork W1999996538 @default.
• W2324894503 hasRelatedWork W2006949239 @default.
• W2324894503 hasRelatedWork W2012608189 @default.
• W2324894503 hasRelatedWork W2037158920 @default.
• W2324894503 hasRelatedWork W2044306932 @default.
• W2324894503 hasRelatedWork W2065706625 @default.
• W2324894503 hasRelatedWork W2071195125 @default.
• W2324894503 hasRelatedWork W2094277477 @default.
• W2324894503 hasRelatedWork W2095309291 @default.
• W2324894503 hasRelatedWork W2140006311 @default.
• W2324894503 hasRelatedWork W2241740977 @default.
• W2324894503 hasRelatedWork W2330627936 @default.
• W2324894503 hasRelatedWork W2338132520 @default.
• W2324894503 hasRelatedWork W2585433562 @default.
• W2324894503 hasRelatedWork W263914383 @default.
• W2324894503 hasRelatedWork W2753857511 @default.
• W2324894503 hasVolume "108" @default.
• W2324894503 isParatext "false" @default.
• W2324894503 isRetracted "false" @default.
• W2324894503 magId "2324894503" @default.

• next