Matches in SemOpenAlex for { <https://semopenalex.org/work/W2324921492> ?p ?o ?g. }
Showing items 1 to 44 of
44
with 100 items per page.
- W2324921492 endingPage "35" @default.
- W2324921492 startingPage "34" @default.
- W2324921492 abstract "A collaboration of chemists at Cornell University and in the process research group at Merck Research Laboratories, Rahway, N.J., has yielded a commercially viable, highly enantioselective process for manufacturing a promising antiviral drug. The team also has proposed an explanation of the process' remarkable stereoselectivity based on spectroscopic and computational evidence [ J. Am. Chem. Soc. , 120 , 2028 (1998)] The drug candidate is a single-enantiomer benzoxazinone that inhibits viral reverse transcriptases. In clinical studies, it shows promise in treating HIV infections in combination with Merck's indinavir, a drug that inhibits viral proteases. Marketing of the reverse transcriptase inhibitor has been assigned to the joint-venture DuPont-Merck Pharmaceutical, which is expected to file a newdrug application with the Food & Drug Administration this year. The medicinal chemists who discovered the reverse transcriptase inhibitor at Merck made it by resolving a racemate. That approach entails throwin..." @default.
- W2324921492 created "2016-06-24" @default.
- W2324921492 creator A5010712397 @default.
- W2324921492 date "1998-03-09" @default.
- W2324921492 modified "2023-09-25" @default.
- W2324921492 title "Self-organization of reagents yields high enantioselectivity" @default.
- W2324921492 doi "https://doi.org/10.1021/cen-v076n010.p034" @default.
- W2324921492 hasPublicationYear "1998" @default.
- W2324921492 type Work @default.
- W2324921492 sameAs 2324921492 @default.
- W2324921492 citedByCount "0" @default.
- W2324921492 crossrefType "journal-article" @default.
- W2324921492 hasAuthorship W2324921492A5010712397 @default.
- W2324921492 hasConcept C144133560 @default.
- W2324921492 hasConcept C178790620 @default.
- W2324921492 hasConcept C185592680 @default.
- W2324921492 hasConcept C21951064 @default.
- W2324921492 hasConcept C40875361 @default.
- W2324921492 hasConceptScore W2324921492C144133560 @default.
- W2324921492 hasConceptScore W2324921492C178790620 @default.
- W2324921492 hasConceptScore W2324921492C185592680 @default.
- W2324921492 hasConceptScore W2324921492C21951064 @default.
- W2324921492 hasConceptScore W2324921492C40875361 @default.
- W2324921492 hasIssue "10" @default.
- W2324921492 hasLocation W23249214921 @default.
- W2324921492 hasOpenAccess W2324921492 @default.
- W2324921492 hasPrimaryLocation W23249214921 @default.
- W2324921492 hasRelatedWork W1970587968 @default.
- W2324921492 hasRelatedWork W2020458665 @default.
- W2324921492 hasRelatedWork W2058529431 @default.
- W2324921492 hasRelatedWork W2145535646 @default.
- W2324921492 hasRelatedWork W2316262187 @default.
- W2324921492 hasRelatedWork W2341011754 @default.
- W2324921492 hasRelatedWork W2950248828 @default.
- W2324921492 hasRelatedWork W2952256733 @default.
- W2324921492 hasRelatedWork W2952561289 @default.
- W2324921492 hasRelatedWork W2953155228 @default.
- W2324921492 hasVolume "76" @default.
- W2324921492 isParatext "false" @default.
- W2324921492 isRetracted "false" @default.
- W2324921492 magId "2324921492" @default.
- W2324921492 workType "article" @default.