Matches in SemOpenAlex for { <https://semopenalex.org/work/W2324952973> ?p ?o ?g. }
Showing items 1 to 66 of
66
with 100 items per page.
- W2324952973 abstract "Rationale: This research aimed to assess if the breath test using 13C-galactose can discriminate healthy children from galactosemic children. Methods: Objectives: (1) Set a cut off point for detecting galactosemia through breath test by constructing a ROC curve. (2) Assess the galactose oxidation ability in healthy children. (3) Assess the galactose oxidation ability in galactosemic children. Methodology: Sampling: 21 healthy children and 7 children with galactosemia with age ranging from 1 to 7 years. Breath test: the breath test of all the children was quantitative for CO2 enrichment in exhaled air before and after oral administration of 7mg/kg of 1-13C-Galactose aqueous solution. Samples were collected at baseline time, 30, 60 and 120min after solution administration. Measurement of the CO2 in the air: molar ratio CO2 and CO2 were quantified by the mass/charge ratio (m/z) of stable isotopes through a mass spectrometer in every air sample. Statistical analysis: ROC curve construction in order to determine the best cutting point of differences in percentage of 1-13C-galactose recovered in CO2 that provides a positive breath test for galactosemia detection. Results: Sick children had some percentage of cumulative 13C in the exhaled air from labeled galactose (CUMPCD) ranging from 0.03% in 30 minutes time to 1.67% in 120 minutes. In contrast, healthy subjects showed a CUMPCD much more expressive, with values ranging from 0.4% in 30 minutes to 5.58% in 120 minutes. Conclusion: This study has shown that there is a great difference in galactose oxidation in children with and without galactosemia, hence the breath test is useful in discriminating children with GALT deficiencies. There is no conflict of interest in this study." @default.
- W2324952973 created "2016-06-24" @default.
- W2324952973 creator A5016801785 @default.
- W2324952973 creator A5061242829 @default.
- W2324952973 date "2014-09-01" @default.
- W2324952973 modified "2023-09-24" @default.
- W2324952973 title "PP246-MON: Galactose Oxidation Using C in Healthy and Galactosemic Children" @default.
- W2324952973 doi "https://doi.org/10.1016/s0261-5614(14)50580-8" @default.
- W2324952973 hasPublicationYear "2014" @default.
- W2324952973 type Work @default.
- W2324952973 sameAs 2324952973 @default.
- W2324952973 citedByCount "0" @default.
- W2324952973 crossrefType "journal-article" @default.
- W2324952973 hasAuthorship W2324952973A5016801785 @default.
- W2324952973 hasAuthorship W2324952973A5061242829 @default.
- W2324952973 hasConcept C126322002 @default.
- W2324952973 hasConcept C185592680 @default.
- W2324952973 hasConcept C2775981797 @default.
- W2324952973 hasConcept C2776409635 @default.
- W2324952973 hasConcept C2778173381 @default.
- W2324952973 hasConcept C2779274956 @default.
- W2324952973 hasConcept C42219234 @default.
- W2324952973 hasConcept C43396882 @default.
- W2324952973 hasConcept C55493867 @default.
- W2324952973 hasConcept C71924100 @default.
- W2324952973 hasConcept C76318530 @default.
- W2324952973 hasConcept C90924648 @default.
- W2324952973 hasConceptScore W2324952973C126322002 @default.
- W2324952973 hasConceptScore W2324952973C185592680 @default.
- W2324952973 hasConceptScore W2324952973C2775981797 @default.
- W2324952973 hasConceptScore W2324952973C2776409635 @default.
- W2324952973 hasConceptScore W2324952973C2778173381 @default.
- W2324952973 hasConceptScore W2324952973C2779274956 @default.
- W2324952973 hasConceptScore W2324952973C42219234 @default.
- W2324952973 hasConceptScore W2324952973C43396882 @default.
- W2324952973 hasConceptScore W2324952973C55493867 @default.
- W2324952973 hasConceptScore W2324952973C71924100 @default.
- W2324952973 hasConceptScore W2324952973C76318530 @default.
- W2324952973 hasConceptScore W2324952973C90924648 @default.
- W2324952973 hasLocation W23249529731 @default.
- W2324952973 hasOpenAccess W2324952973 @default.
- W2324952973 hasPrimaryLocation W23249529731 @default.
- W2324952973 hasRelatedWork W152938456 @default.
- W2324952973 hasRelatedWork W1966751246 @default.
- W2324952973 hasRelatedWork W1983513176 @default.
- W2324952973 hasRelatedWork W1996865584 @default.
- W2324952973 hasRelatedWork W2006080709 @default.
- W2324952973 hasRelatedWork W2020722736 @default.
- W2324952973 hasRelatedWork W2020941307 @default.
- W2324952973 hasRelatedWork W2023277822 @default.
- W2324952973 hasRelatedWork W2031137949 @default.
- W2324952973 hasRelatedWork W2038435038 @default.
- W2324952973 hasRelatedWork W2039783493 @default.
- W2324952973 hasRelatedWork W2046827165 @default.
- W2324952973 hasRelatedWork W2073901214 @default.
- W2324952973 hasRelatedWork W2114602564 @default.
- W2324952973 hasRelatedWork W2224102484 @default.
- W2324952973 hasRelatedWork W2298108971 @default.
- W2324952973 hasRelatedWork W2332531938 @default.
- W2324952973 hasRelatedWork W2388449999 @default.
- W2324952973 hasRelatedWork W2412656684 @default.
- W2324952973 hasRelatedWork W2910060144 @default.
- W2324952973 isParatext "false" @default.
- W2324952973 isRetracted "false" @default.
- W2324952973 magId "2324952973" @default.
- W2324952973 workType "article" @default.