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• W2324954888 abstract "You have accessJournal of UrologyPediatrics: Testis, Varicocele & Stones1 Apr 2016MP43-07 FACTORS ASSOCIATED WITH RECURRENT PEDIATRIC UROLITHIASIS: A MULTI-INSTITUTIONAL ANALYSIS Theodore Saitz, Solange Mongoue-Tchokote, Cynthia Sharadin, Dana Giel, Sean Corbett, and Aaron Bayne Theodore SaitzTheodore Saitz More articles by this author , Solange Mongoue-TchokoteSolange Mongoue-Tchokote More articles by this author , Cynthia SharadinCynthia Sharadin More articles by this author , Dana GielDana Giel More articles by this author , Sean CorbettSean Corbett More articles by this author , and Aaron BayneAaron Bayne More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2016.02.216AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Urinary stone disease is relatively rare in children and little is known regarding stone recurrence. We compared potential risk factors to include urinary metabolic profiles and stone analysis in children with a solitary stone episode to those with recurrent stone episodes. METHODS A multi-institutional retrospective study was performed to assess urinary metabolic profiles in children aged 2-18 years old with any urolithiasis. The patients were stratified based upon review of medical record. Twenty-four hour urine collections were performed and evaluated, along with analysis of stone fragments when available. Urine chemistries were adjusted for creatinine and weight. Differences in mean urine collections between the two groups were assessed using two-tailed t-tests. Chi-square tests were used to test the association between gender, stone type and recurrence status. Multivariate analyses were performed using general linear models, allowing us to account for age, BMI, stone analysis and site. P values <0.05 were considered statistically significant. RESULTS A total of 231 samples from 109 patients with a solitary stone episode and 122 with recurrent stone episodes were examined. Patients with recurrent stone disease were older than patients with a single stone (Mean±SD: 13.3±3.5 years vs. 11.7±3.9 years, p=.0020). Females were more likely to have recurrent stones than males (63% vs 42%, p=0.0014). Stone analysis and patient BMI were not associated with recurrence (p=0.1790 and p=0.7218, respectively). Abnormal values for citrate were associated with recurrent stone disease in multivariate analysis (p 0.0084), while abnormal values for calcium were associated with recurrence in univariate (p=0.0223) and multivariate analysis (p=0.0085). Centers located in the Southeast of the United States had higher rates of recurrence compared to the West (Tennessee 62.4%, Virginia 44.4%, Oregon 30.9%, p=0.0002). CONCLUSIONS Abnormal urinary calcium and citrate levels are associated with recurrent stone disease in children. Children living in “The Stone Belt” seem to be at higher risk for recurrence. Metabolic evaluation of patients with stones may help stratify patients that are likely to form recurrent stones and are amenable to increased surveillance, and dietary or pharmacologic intervention. © 2016FiguresReferencesRelatedDetails Volume 195Issue 4SApril 2016Page: e580-e581 Advertisement Copyright & Permissions© 2016MetricsAuthor Information Theodore Saitz More articles by this author Solange Mongoue-Tchokote More articles by this author Cynthia Sharadin More articles by this author Dana Giel More articles by this author Sean Corbett More articles by this author Aaron Bayne More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ..." @default.
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• W2324954888 title "MP43-07 FACTORS ASSOCIATED WITH RECURRENT PEDIATRIC UROLITHIASIS: A MULTI-INSTITUTIONAL ANALYSIS" @default.
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