Matches in SemOpenAlex for { <https://semopenalex.org/work/W2324956847> ?p ?o ?g. }
- W2324956847 endingPage "62" @default.
- W2324956847 startingPage "51" @default.
- W2324956847 abstract "Protein prenylation is a ubiquitous covalent post-translational modification found in all eukaryotic cells, comprising attachment of either a farnesyl or a geranylgeranyl isoprenoid. It is essential for the proper cellular activity of numerous proteins, including Ras family GTPases and heterotrimeric G-proteins. Inhibition of prenylation has been extensively investigated to suppress the activity of oncogenic Ras proteins to achieve antitumor activity. Here, we review the biochemistry of the prenyltransferase enzymes and numerous isoprenoid analogs synthesized to investigate various aspects of prenylation and prenyltransferases. We also give an account of the current status of prenyltransferase inhibitors as potential therapeutics against several diseases including cancers, progeria, aging, parasitic diseases, and bacterial and viral infections. Finally, we discuss recent progress in utilizing protein prenylation for site-specific protein labeling for various biotechnology applications." @default.
- W2324956847 created "2016-06-24" @default.
- W2324956847 creator A5048332389 @default.
- W2324956847 creator A5075389749 @default.
- W2324956847 date "2014-12-08" @default.
- W2324956847 modified "2023-10-17" @default.
- W2324956847 title "Protein Prenylation: Enzymes, Therapeutics, and Biotechnology Applications" @default.
- W2324956847 cites W1032877256 @default.
- W2324956847 cites W1491433568 @default.
- W2324956847 cites W1527765993 @default.
- W2324956847 cites W1553551356 @default.
- W2324956847 cites W1564406238 @default.
- W2324956847 cites W1790645982 @default.
- W2324956847 cites W1963599691 @default.
- W2324956847 cites W1963631453 @default.
- W2324956847 cites W1965547596 @default.
- W2324956847 cites W1968284627 @default.
- W2324956847 cites W1971015478 @default.
- W2324956847 cites W1972433289 @default.
- W2324956847 cites W1973097976 @default.
- W2324956847 cites W1975186922 @default.
- W2324956847 cites W1975805439 @default.
- W2324956847 cites W1976252923 @default.
- W2324956847 cites W1977189841 @default.
- W2324956847 cites W1977345497 @default.
- W2324956847 cites W1977860801 @default.
- W2324956847 cites W1979053057 @default.
- W2324956847 cites W1979071042 @default.
- W2324956847 cites W1980775545 @default.
- W2324956847 cites W1981866993 @default.
- W2324956847 cites W1982764450 @default.
- W2324956847 cites W1983647569 @default.
- W2324956847 cites W1984134606 @default.
- W2324956847 cites W1984994607 @default.
- W2324956847 cites W1985238450 @default.
- W2324956847 cites W1985384799 @default.
- W2324956847 cites W1988480515 @default.
- W2324956847 cites W1990524685 @default.
- W2324956847 cites W1990690495 @default.
- W2324956847 cites W1991867962 @default.
- W2324956847 cites W1991883335 @default.
- W2324956847 cites W1996012633 @default.
- W2324956847 cites W1996908905 @default.
- W2324956847 cites W2002151030 @default.
- W2324956847 cites W2002252224 @default.
- W2324956847 cites W2002986759 @default.
- W2324956847 cites W2003394217 @default.
- W2324956847 cites W2004452311 @default.
- W2324956847 cites W2009648966 @default.
- W2324956847 cites W2014451351 @default.
- W2324956847 cites W2014721850 @default.
- W2324956847 cites W2016033634 @default.
- W2324956847 cites W2016268789 @default.
- W2324956847 cites W2019408526 @default.
- W2324956847 cites W2020120027 @default.
- W2324956847 cites W2020302087 @default.
- W2324956847 cites W2023060014 @default.
- W2324956847 cites W2023433298 @default.
- W2324956847 cites W2025540691 @default.
- W2324956847 cites W2027530605 @default.
- W2324956847 cites W2028232266 @default.
- W2324956847 cites W2029143430 @default.
- W2324956847 cites W2032136764 @default.
- W2324956847 cites W2033120008 @default.
- W2324956847 cites W2035654066 @default.
- W2324956847 cites W2038051211 @default.
- W2324956847 cites W2038867709 @default.
- W2324956847 cites W2039266469 @default.
- W2324956847 cites W2040171181 @default.
- W2324956847 cites W2041433880 @default.
- W2324956847 cites W2041713157 @default.
- W2324956847 cites W2041797751 @default.
- W2324956847 cites W2041967216 @default.
- W2324956847 cites W2045255148 @default.
- W2324956847 cites W2048180102 @default.
- W2324956847 cites W2050948326 @default.
- W2324956847 cites W2050978280 @default.
- W2324956847 cites W2051650708 @default.
- W2324956847 cites W2054650958 @default.
- W2324956847 cites W2054652123 @default.
- W2324956847 cites W2056264942 @default.
- W2324956847 cites W2060264934 @default.
- W2324956847 cites W2061620258 @default.
- W2324956847 cites W2063165599 @default.
- W2324956847 cites W2063281249 @default.
- W2324956847 cites W2064352582 @default.
- W2324956847 cites W2065507415 @default.
- W2324956847 cites W2066181904 @default.
- W2324956847 cites W2067100185 @default.
- W2324956847 cites W2067153023 @default.
- W2324956847 cites W2067916965 @default.
- W2324956847 cites W2069286623 @default.
- W2324956847 cites W2074797041 @default.
- W2324956847 cites W2075079950 @default.
- W2324956847 cites W2075083633 @default.
- W2324956847 cites W2077231529 @default.
- W2324956847 cites W2078086283 @default.
- W2324956847 cites W2078762416 @default.