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- W2324960057 abstract "Polyamine toxins from orb weaver spiders are attractive pharmacological tools particularly for studies of ionotropic glutamate (iGlu) receptors in the brain. These polyamine toxins are biosynthesized in a combinatorial manner, providing a plethora of related, but structurally complex toxins to be exploited in biological studies. Here, we have used solid-phase synthetic methodology for the efficient synthesis of Joro spider toxin-4 (JSTX-4) (1) from Nephila clavata, providing sufficient amounts of the toxin for biological evaluation at iGlu receptor subtypes using electrophysiology. Biological evaluation revealed that JSTX-4 inhibits iGlu receptors only in high μM concentrations, thereby being substantially less potent than structurally related polyamine toxins." @default.
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- W2324960057 date "2010-12-28" @default.
- W2324960057 modified "2023-09-26" @default.
- W2324960057 title "Solid-Phase Synthesis and Biological Evaluation of Joro Spider Toxin-4 from <i>Nephila clavata</i>" @default.
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- W2324960057 doi "https://doi.org/10.1021/np100746w" @default.
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