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- W2324970138 abstract "We report the use of atomic force microscopy (AFM) to study Sox2–Pax6 complex formation on the regulatory DNA element at a single molecule level. Using an origami DNA scaffold containing two DNA strands with different levels of tensile force, we confirmed that DNA bending is necessary for Sox2 binding. We also demonstrated that two transcription factors bind cooperatively by observing the increased occupancy of Sox2–Pax6 on the DNA element compared to that of Sox2 alone." @default.
- W2324970138 created "2016-06-24" @default.
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- W2324970138 date "2014-04-04" @default.
- W2324970138 modified "2023-10-14" @default.
- W2324970138 title "Single Molecule Visualization and Characterization of Sox2–Pax6 Complex Formation on a Regulatory DNA Element Using a DNA Origami Frame" @default.
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- W2324970138 doi "https://doi.org/10.1021/nl4044949" @default.
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