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• W2324974336 abstract "Mercury is a highly toxic metal which induces oxidative stress in the body. The present study aimed to investigate the possible protective effect of neem (Azadirachta indica) leaves extract (NLE) as an antioxidant to protect against mercury-induced oxidative stress and hepatotoxicity. Fourty male albino Sprague Dawley rats were classified into four groups, Control group received distilled water. Mercury-treated group was administrated 2 mg/ Kg b.wt., mercuric chloride (HgCl2). Mercury and NLE-treated group was treated with 200 mg/Kg b.wt of NLE simultaneously with the same dose of HgCl2. NLE-treated group was given NLE only with the same dose. The daily treatments were administered orally for 30 days. Hepatotoxicity was assessed by increased tissue malondialdehyde (MDA), nitric oxide (NO) concentrations, glutathione peroxidase (GPx) activity, serum total bilirubin, direct bilirubin concentrations, serum activities of alanine aminotransferase (ALT), aspartate aminotransferase; (AST), and alkaline phosphatase (ALP) enzymes and decreased hepatic content of reduced glutathione (GSH), vitamin C, vitamin E and serum albumin concentration. Moreover, the histopathological changes revealed destruction of the normal hepatic architecture and severe pathological alterations post HgCl2 treatment. Carbohydrates, DNA and proteins contents were decreased in the liver tissue. The ultrastructural alterations were represented by degenerative features which covered all the hepatic cells and their cytoplasm contained extensive necrotic areas. Many lipid droplets dispersed within the hepatic cells in addition to the disintegration of most cellular contents. On the other hand, treatment of rats with NLE reversed all these biochemical indices, histopathological, histochemical and ultrastructural alterations. The levels of various serum and tissue parameters for organ toxicity after neem treatment at the dose of 200 mg/kg.b.wt. remained more or less close to the normal values suggesting no significant adverse effects of NLE. The present results implicate that mercury-induced oxidative damage in hepatic tissues was improved by neem leaves extract, with its antioxidant effects. (Journal of American Science 2010; 6(9):735-751). (ISSN: 1545-1003)." @default.
• W2324974336 created "2016-06-24" @default.
• W2324974336 creator A5027601292 @default.
• W2324974336 creator A5070116289 @default.
• W2324974336 creator A5075027770 @default.
• W2324974336 date "2010-01-01" @default.
• W2324974336 modified "2023-09-23" @default.
• W2324974336 title "Hepato Ameliorative Effect of Azadirachta indica Leaves Extract against Mercuric Chloride Environmental Pollution." @default.
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