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- W2324974776 abstract "<h3>Objective</h3> To explore the clinical value of different dosage of valsartan in treatment of chronic heartfailure (CHF). <h3>Methods</h3> 99 patient s with CHF were randomly divided into three groups: benazepril group (group A, 10 mg/d), conventional dose valsartan group (group B, 80 mg/d) and high dose valsartan group (groups C, 80 mg/d, 2 times per day). Levels of Angiotensin II (Ang II), aldosterone (ALD) and brain nat riuretic peptide (BNP) were detected, and the changes of left ventricular ejection fraction (LVEF) were measured before and 6 months after treatment. <h3>Results</h3> BNP, ALD, Ang II were decreased significantly in 3 groups (p<0.05), while LVEF increased significantly (p<0.05) after the treatment. Compared with those of group A and B, BNP and ALD were significantly decreased while LVEF was significantly increased after treatment in group C (p<0.05). ALD in group B decreased significantly compared with that of group A (p<0.05), while the other indexes were not significantly changed. <h3>Conclusions</h3> Valsartan, similar to benazepril, reverses ventricular remodelling and improves cardiac function, high dose valsartan reverses ventricular remodelling and improves cardiac function more effectively than benazepril and conventional dose valsartan." @default.
- W2324974776 created "2016-06-24" @default.
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- W2324974776 date "2010-10-01" @default.
- W2324974776 modified "2023-09-23" @default.
- W2324974776 title "e0349 Clinical observation on different dosage of valsartan in treatment of heart failure" @default.
- W2324974776 doi "https://doi.org/10.1136/hrt.2010.208967.349" @default.
- W2324974776 hasPublicationYear "2010" @default.
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