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• W2324989776 endingPage "16988" @default.
• W2324989776 startingPage "16979" @default.
• W2324989776 abstract "Protein aggregation is associated with many “protein deposition diseases”. A precise molecular detail of the conformational transitions of such a membrane-associated protein structure is critical to understand the disease mechanism and develop effective treatments. One potential model peptide for studying the mechanism of protein deposition diseases is prion protein fragment [118–135] (PrP118–135), which shares homology with the C-terminal domain of the Alzheimer’s β-amyloid peptide. In this study, sum frequency generation vibrational spectroscopy (SFG-VS) has been applied to characterize interactions between PrP118–135 and 1-palmitoyl-2-oleoyl-sn-glycero-3-phospho-(1′-rac-glycerol) (POPG) lipid bilayer in situ. The conformation change and orientation of PrP118–135 in lipid bilayers have been determined using SFG spectra with different polarization combinations. It is found that low-concentration PrP118–135 predominantly adopts α-helical structure but with tiny β-sheet structure. With the PrP118–135 concentration increasing, the molecular number ratio of parallel β-sheet structure increases and reaches about 44% at a concentration of 0.10 mg/mL, indicating the formation of abnormally folded scrapie isoforms. The α-helical structure inserts into the lipid bilayer with a tilt angle of ∼32° versus the surface normal, while the β-sheet structure lies down on the lipid bilayer with the tilt and twist angle both of 90°. The 3300 cm–1 N–H stretching signal in psp spectra arises from α-helical structure at low PrP concentration and from the β-sheet structure at high PrP concentration. Results from this study will provide an in-depth insight into the early events in the aggregation of PrP in cell membrane." @default.
• W2324989776 created "2016-06-24" @default.
• W2324989776 creator A5008880759 @default.
• W2324989776 creator A5010439700 @default.
• W2324989776 creator A5043124433 @default.
• W2324989776 creator A5057282533 @default.
• W2324989776 creator A5078771565 @default.
• W2324989776 date "2012-11-29" @default.
• W2324989776 modified "2023-09-26" @default.
• W2324989776 title "In Situ Molecular-Level Insights into the Interfacial Structure Changes of Membrane-Associated Prion Protein Fragment [118–135] Investigated by Sum Frequency Generation Vibrational Spectroscopy" @default.
• W2324989776 cites W1583440911 @default.
• W2324989776 cites W1963489430 @default.
• W2324989776 cites W1972409470 @default.
• W2324989776 cites W1973096804 @default.
• W2324989776 cites W1973752746 @default.
• W2324989776 cites W1973897761 @default.
• W2324989776 cites W1974000116 @default.
• W2324989776 cites W1974433806 @default.
• W2324989776 cites W1977343510 @default.
• W2324989776 cites W1980035515 @default.
• W2324989776 cites W1981678822 @default.
• W2324989776 cites W1983403732 @default.
• W2324989776 cites W1984191886 @default.
• W2324989776 cites W1990383225 @default.
• W2324989776 cites W1998262071 @default.
• W2324989776 cites W1998622466 @default.
• W2324989776 cites W2000427115 @default.
• W2324989776 cites W2001148193 @default.
• W2324989776 cites W2003020823 @default.
• W2324989776 cites W2003670177 @default.
• W2324989776 cites W2005279391 @default.
• W2324989776 cites W2010433544 @default.
• W2324989776 cites W2012455318 @default.
• W2324989776 cites W2013021944 @default.
• W2324989776 cites W2013993958 @default.
• W2324989776 cites W2015081640 @default.
• W2324989776 cites W2019570308 @default.
• W2324989776 cites W2020258831 @default.
• W2324989776 cites W2022392367 @default.
• W2324989776 cites W2023326634 @default.
• W2324989776 cites W2026534774 @default.
• W2324989776 cites W2029440340 @default.
• W2324989776 cites W2030396430 @default.
• W2324989776 cites W2034337706 @default.
• W2324989776 cites W2036452049 @default.
• W2324989776 cites W2037855380 @default.
• W2324989776 cites W2040211368 @default.
• W2324989776 cites W2040273128 @default.
• W2324989776 cites W2050207511 @default.
• W2324989776 cites W2050407809 @default.
• W2324989776 cites W2052100687 @default.
• W2324989776 cites W2052412840 @default.
• W2324989776 cites W2052510372 @default.
• W2324989776 cites W2053636966 @default.
• W2324989776 cites W2058535177 @default.
• W2324989776 cites W2059804089 @default.
• W2324989776 cites W2064724563 @default.
• W2324989776 cites W2064931700 @default.
• W2324989776 cites W2067212206 @default.
• W2324989776 cites W2067397150 @default.
• W2324989776 cites W2067821192 @default.
• W2324989776 cites W2071375115 @default.
• W2324989776 cites W2071542581 @default.
• W2324989776 cites W2071599845 @default.
• W2324989776 cites W2074931526 @default.
• W2324989776 cites W2075302473 @default.
• W2324989776 cites W2078663260 @default.
• W2324989776 cites W2080429643 @default.
• W2324989776 cites W2082197002 @default.
• W2324989776 cites W2083068181 @default.
• W2324989776 cites W2084114424 @default.
• W2324989776 cites W2089245987 @default.
• W2324989776 cites W2094337931 @default.
• W2324989776 cites W2095402560 @default.
• W2324989776 cites W2097965815 @default.
• W2324989776 cites W2107036307 @default.
• W2324989776 cites W2109458069 @default.
• W2324989776 cites W2111249363 @default.
• W2324989776 cites W2114335213 @default.
• W2324989776 cites W2115706239 @default.
• W2324989776 cites W2118966800 @default.
• W2324989776 cites W2119200410 @default.
• W2324989776 cites W2129583700 @default.
• W2324989776 cites W2137419733 @default.
• W2324989776 cites W2137495988 @default.
• W2324989776 cites W2138163763 @default.
• W2324989776 cites W2138823948 @default.
• W2324989776 cites W2140031084 @default.
• W2324989776 cites W2141970481 @default.
• W2324989776 cites W2146129321 @default.
• W2324989776 cites W2147443012 @default.
• W2324989776 cites W2148669320 @default.
• W2324989776 cites W2148934219 @default.
• W2324989776 cites W2162504167 @default.
• W2324989776 cites W2162741488 @default.
• W2324989776 cites W2165186407 @default.
• W2324989776 cites W2165801834 @default.
• W2324989776 cites W2317692892 @default.

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