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W2324994433 abstract "Lactoferrin supplementation suppresses ultraviolet light B (UV-B)-induced oxidation of cultures of human corneal epithelial cells. To investigate the protective effect of lactoferrin containing eyedrops against UV-B-induced corneal damage in vivo, we examined lactoferrin efficacy in a rat UV-B keratitis model.Sprague-Dawley rats were irradiated with >10 kJ/m2 after anesthetization, and then corneal epithelial defect was observed at 24 h postirradiation. The pre- or postapplication of vehicle or lactoferrin-containing eyedrops was performed, and then corneal epithelial damage was scored based on fluorescein staining.Posttreatment with lactoferrin did not inhibit the extent of corneal damage and did not affect wound healing. However, pretreatment by topical application of lactoferrin suppressed development of a corneal epithelial defect induced by UV-B irradiation in rats.These results suggest that the presence of lactoferrin in human tear fluid may inhibit UV-induced corneal epithelial damage." @default.
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W2324994433 date "2000-03-01" @default.
W2324994433 modified "2023-09-27" @default.
W2324994433 title "Lactoferrin Protects Against UV-B Irradiation–Induced Corneal Epithelial Damage in Rats" @default.
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W2324994433 doi "https://doi.org/10.1097/00003226-200003000-00015" @default.
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