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• W2324997630 abstract "Exogenous substance P accelerates wound healing in diabetes, but the mechanism remains poorly understood. Here, we established a rat model by intraperitoneally injecting streptozotocin. Four wounds (1.8 cm diameter) were drilled using a self-made punch onto the back, bilateral to the vertebral column, and then treated using amniotic membrane with epidermal stem cells and/or substance P around and in the middle of the wounds. With the combined treatment the wound-healing rate was 100% at 14 days. With prolonged time, type I collagen content gradually increased, yet type III collagen content gradually diminished. Abundant protein gene product 9.5- and substance P-immunoreactive nerve fibers regenerated. Partial nerve fiber endings extended to the epidermis. The therapeutic effects of combined substance P and epidermal stem cells were better than with amniotic membrane and either factor alone. Our results suggest that the combination of substance P and epidermal stem cells effectively contributes to nerve regeneration and wound healing in diabetic rats." @default.
• W2324997630 created "2016-06-24" @default.
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• W2324997630 date "2016-01-01" @default.
• W2324997630 modified "2023-10-03" @default.
• W2324997630 title "Substance P combined with epidermal stem cells promotes wound healing and nerve regeneration in diabetes mellitus" @default.
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• W2324997630 doi "https://doi.org/10.4103/1673-5374.179073" @default.
• W2324997630 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4829018" @default.
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