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- W2325072505 abstract "The development of a scalable framework for biodesign automation is a formidable challenge given the expected increase in part availability and the ever-growing complexity of synthetic circuits. To allow for (a) the use of previously constructed and characterized circuits or modules and (b) the implementation of designs that can scale up to hundreds of nodes, we here propose a divide-and-conquer Synthetic Biology Reusable Optimization Methodology (SBROME). An abstract user-defined circuit is first transformed and matched against a module database that incorporates circuits that have previously been experimentally characterized. Then the resulting circuit is decomposed to subcircuits that are populated with the set of parts that best approximate the desired function. Finally, all subcircuits are subsequently characterized and deposited back to the module database for future reuse. We successfully applied SBROME toward two alternative designs of a modular 3-input multiplexer that utilize pre-existing logic gates and characterized biological parts." @default.
- W2325072505 created "2016-06-24" @default.
- W2325072505 creator A5004351739 @default.
- W2325072505 creator A5005935921 @default.
- W2325072505 creator A5040810487 @default.
- W2325072505 creator A5091730054 @default.
- W2325072505 date "2013-03-11" @default.
- W2325072505 modified "2023-09-25" @default.
- W2325072505 title "SBROME: A Scalable Optimization and Module Matching Framework for Automated Biosystems Design" @default.
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- W2325072505 doi "https://doi.org/10.1021/sb300095m" @default.
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