Matches in SemOpenAlex for { <https://semopenalex.org/work/W2325101476> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W2325101476 endingPage "536" @default.
- W2325101476 startingPage "529" @default.
- W2325101476 abstract "This review examines the impact of the endocannabinoid signaling system on metabolic and cardiovascular health and the new therapeutic strategies that selectively target dysfunctional endocannabinoid action in peripheral tissues, without causing the undesirable central nervous system effects that occurred with the first-generation of CB1 receptor blockers. We first review the components of the endocannabinoid system and the enzymes that synthesize and degrade the endocannabinoids, the critical role of the system in the homeostasis of energy balance, and its hedonic aspects related to the incentive and motivational value of food. Second, we describe the central and peripheral actions of the endocannabinoid system and its interactions with other biological modulators, such as ghrelin and leptin. Third, we summarize data from human clinical trials with the CB1 inverse agonist rimonabant, showing that the drug, although effective in increasing weight loss with accompanying improvements in the metabolic profile of the participants in the RIO (Rimonabant In Obesity) trials, was withdrawn from the market because of the risk of serious adverse events. Finally, we describe: 1) the development of new selective peripheral blockers that interrupt endocannabinoid action selectively in peripheral tissues and that have been suggested as an alternative approach to treat the metabolic consequences of obesity and related diseases, without undesirable central nervous system effects, and 2) the potential for inhibition of enzymes of synthesis, as well as the possible role of endocannabinoid congeners, with opposing effects as compared to CB1 receptor agonists, in the control of metabolic disorders." @default.
- W2325101476 created "2016-06-24" @default.
- W2325101476 creator A5007484138 @default.
- W2325101476 creator A5017856270 @default.
- W2325101476 creator A5037626367 @default.
- W2325101476 creator A5057706712 @default.
- W2325101476 date "2014-05-27" @default.
- W2325101476 modified "2023-10-02" @default.
- W2325101476 title "The Endocannabinoid System – Back to the Scene of Cardiometabolic Risk Factors Control?" @default.
- W2325101476 doi "https://doi.org/10.1055/s-0034-1375653" @default.
- W2325101476 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24867141" @default.
- W2325101476 hasPublicationYear "2014" @default.
- W2325101476 type Work @default.
- W2325101476 sameAs 2325101476 @default.
- W2325101476 citedByCount "15" @default.
- W2325101476 countsByYear W23251014762015 @default.
- W2325101476 countsByYear W23251014762016 @default.
- W2325101476 countsByYear W23251014762017 @default.
- W2325101476 countsByYear W23251014762018 @default.
- W2325101476 countsByYear W23251014762019 @default.
- W2325101476 countsByYear W23251014762020 @default.
- W2325101476 countsByYear W23251014762021 @default.
- W2325101476 countsByYear W23251014762023 @default.
- W2325101476 crossrefType "journal-article" @default.
- W2325101476 hasAuthorship W2325101476A5007484138 @default.
- W2325101476 hasAuthorship W2325101476A5017856270 @default.
- W2325101476 hasAuthorship W2325101476A5037626367 @default.
- W2325101476 hasAuthorship W2325101476A5057706712 @default.
- W2325101476 hasConcept C126322002 @default.
- W2325101476 hasConcept C134018914 @default.
- W2325101476 hasConcept C148001335 @default.
- W2325101476 hasConcept C169760540 @default.
- W2325101476 hasConcept C170493617 @default.
- W2325101476 hasConcept C2491326 @default.
- W2325101476 hasConcept C2776433454 @default.
- W2325101476 hasConcept C2778938600 @default.
- W2325101476 hasConcept C2780100140 @default.
- W2325101476 hasConcept C2780613262 @default.
- W2325101476 hasConcept C2780871563 @default.
- W2325101476 hasConcept C2781144285 @default.
- W2325101476 hasConcept C46721173 @default.
- W2325101476 hasConcept C511355011 @default.
- W2325101476 hasConcept C71924100 @default.
- W2325101476 hasConcept C86803240 @default.
- W2325101476 hasConcept C89951826 @default.
- W2325101476 hasConcept C98274493 @default.
- W2325101476 hasConceptScore W2325101476C126322002 @default.
- W2325101476 hasConceptScore W2325101476C134018914 @default.
- W2325101476 hasConceptScore W2325101476C148001335 @default.
- W2325101476 hasConceptScore W2325101476C169760540 @default.
- W2325101476 hasConceptScore W2325101476C170493617 @default.
- W2325101476 hasConceptScore W2325101476C2491326 @default.
- W2325101476 hasConceptScore W2325101476C2776433454 @default.
- W2325101476 hasConceptScore W2325101476C2778938600 @default.
- W2325101476 hasConceptScore W2325101476C2780100140 @default.
- W2325101476 hasConceptScore W2325101476C2780613262 @default.
- W2325101476 hasConceptScore W2325101476C2780871563 @default.
- W2325101476 hasConceptScore W2325101476C2781144285 @default.
- W2325101476 hasConceptScore W2325101476C46721173 @default.
- W2325101476 hasConceptScore W2325101476C511355011 @default.
- W2325101476 hasConceptScore W2325101476C71924100 @default.
- W2325101476 hasConceptScore W2325101476C86803240 @default.
- W2325101476 hasConceptScore W2325101476C89951826 @default.
- W2325101476 hasConceptScore W2325101476C98274493 @default.
- W2325101476 hasIssue "08" @default.
- W2325101476 hasLocation W23251014761 @default.
- W2325101476 hasLocation W23251014762 @default.
- W2325101476 hasOpenAccess W2325101476 @default.
- W2325101476 hasPrimaryLocation W23251014761 @default.
- W2325101476 hasRelatedWork W1968800350 @default.
- W2325101476 hasRelatedWork W2076375645 @default.
- W2325101476 hasRelatedWork W2085860270 @default.
- W2325101476 hasRelatedWork W2090705977 @default.
- W2325101476 hasRelatedWork W2105927550 @default.
- W2325101476 hasRelatedWork W2122825268 @default.
- W2325101476 hasRelatedWork W2325101476 @default.
- W2325101476 hasRelatedWork W2417844085 @default.
- W2325101476 hasRelatedWork W2757614918 @default.
- W2325101476 hasRelatedWork W4200374160 @default.
- W2325101476 hasVolume "46" @default.
- W2325101476 isParatext "false" @default.
- W2325101476 isRetracted "false" @default.
- W2325101476 magId "2325101476" @default.
- W2325101476 workType "article" @default.