Matches in SemOpenAlex for { <https://semopenalex.org/work/W2325121566> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W2325121566 abstract "Previous investigators reported that gas exchange consistently worsened when cardiac output (Qt) was increased under normal and pathological conditions. The aim of the present paper is to offer an alternative explanation, besides the one previously proposed that was based on some attenuation of hypoxic pulmonary vasoconstriction. The new concept emphases the inherent heterogeneity of regional blood flow (Q), as well as the skewed relationship between ventilation perfusion ratio (V/Q) and arterial oxygen tension (PaO2). Namely, PaO2 is exquisitely sensitive to any change of V/Q ratio from 0 to 1, which is many times more than that from 1 to 100. As Qt is increased, the additional pulmonary flow is by no means uniformly distributed. Thus, either ventilation (V) remains stable or even becomes more variable, V/Q heterogeneity increases at increased Qt. The higher Q in most regions reduces their corresponding V/Q ratios from the previously normal value of about 0.8 to 1, precipitously into the hypoxic range towards true shunt (V/Q = 0) and increases the V/Q mismatch. In contrary, the simultaneously created higher V/Q units cannot mitigate these adverse changes because of the sigmoid shape of hemoglobin oxygen dissociation curve. By this mechanism, diseased lungs are more susceptible to hypoxemia when Qt is increased due to their pre-existing V/Q abnormalities." @default.
- W2325121566 created "2016-06-24" @default.
- W2325121566 creator A5041063819 @default.
- W2325121566 date "2014-01-01" @default.
- W2325121566 modified "2023-10-04" @default.
- W2325121566 title "Mechanism for Worsening Gas Exchange at Increased Cardiac Output: It’s Time for an Occam’s Razor" @default.
- W2325121566 cites W1247005325 @default.
- W2325121566 cites W141819067 @default.
- W2325121566 cites W1567298338 @default.
- W2325121566 cites W1787652680 @default.
- W2325121566 cites W1790607182 @default.
- W2325121566 cites W1878289269 @default.
- W2325121566 cites W1882473282 @default.
- W2325121566 cites W1899044487 @default.
- W2325121566 cites W1974484469 @default.
- W2325121566 cites W1989028358 @default.
- W2325121566 cites W1989921938 @default.
- W2325121566 cites W2007708062 @default.
- W2325121566 cites W2054958657 @default.
- W2325121566 cites W2059955816 @default.
- W2325121566 cites W2062830996 @default.
- W2325121566 cites W2077788556 @default.
- W2325121566 cites W2080192662 @default.
- W2325121566 cites W2081002120 @default.
- W2325121566 cites W2086822439 @default.
- W2325121566 cites W2092002774 @default.
- W2325121566 cites W2099107856 @default.
- W2325121566 cites W2109792677 @default.
- W2325121566 cites W2111027704 @default.
- W2325121566 cites W2131144720 @default.
- W2325121566 cites W2134593909 @default.
- W2325121566 cites W2134742000 @default.
- W2325121566 cites W2146526610 @default.
- W2325121566 cites W2174287348 @default.
- W2325121566 cites W2179692268 @default.
- W2325121566 cites W2218538068 @default.
- W2325121566 cites W2219827516 @default.
- W2325121566 cites W2227205046 @default.
- W2325121566 cites W2247820841 @default.
- W2325121566 cites W2261966534 @default.
- W2325121566 cites W2278001150 @default.
- W2325121566 cites W2288994306 @default.
- W2325121566 cites W2344124182 @default.
- W2325121566 cites W2399761172 @default.
- W2325121566 cites W2404074738 @default.
- W2325121566 cites W2405897489 @default.
- W2325121566 cites W2407995145 @default.
- W2325121566 cites W2409819355 @default.
- W2325121566 cites W2410361525 @default.
- W2325121566 cites W2415694362 @default.
- W2325121566 cites W2418832902 @default.
- W2325121566 cites W2422688884 @default.
- W2325121566 cites W2429561539 @default.
- W2325121566 doi "https://doi.org/10.4172/2161-105x.1000217" @default.
- W2325121566 hasPublicationYear "2014" @default.
- W2325121566 type Work @default.
- W2325121566 sameAs 2325121566 @default.
- W2325121566 citedByCount "0" @default.
- W2325121566 crossrefType "journal-article" @default.
- W2325121566 hasAuthorship W2325121566A5041063819 @default.
- W2325121566 hasConcept C126322002 @default.
- W2325121566 hasConcept C127503593 @default.
- W2325121566 hasConcept C146957229 @default.
- W2325121566 hasConcept C164705383 @default.
- W2325121566 hasConcept C178790620 @default.
- W2325121566 hasConcept C185592680 @default.
- W2325121566 hasConcept C2776779939 @default.
- W2325121566 hasConcept C2778917026 @default.
- W2325121566 hasConcept C2779961880 @default.
- W2325121566 hasConcept C29323129 @default.
- W2325121566 hasConcept C540031477 @default.
- W2325121566 hasConcept C71924100 @default.
- W2325121566 hasConceptScore W2325121566C126322002 @default.
- W2325121566 hasConceptScore W2325121566C127503593 @default.
- W2325121566 hasConceptScore W2325121566C146957229 @default.
- W2325121566 hasConceptScore W2325121566C164705383 @default.
- W2325121566 hasConceptScore W2325121566C178790620 @default.
- W2325121566 hasConceptScore W2325121566C185592680 @default.
- W2325121566 hasConceptScore W2325121566C2776779939 @default.
- W2325121566 hasConceptScore W2325121566C2778917026 @default.
- W2325121566 hasConceptScore W2325121566C2779961880 @default.
- W2325121566 hasConceptScore W2325121566C29323129 @default.
- W2325121566 hasConceptScore W2325121566C540031477 @default.
- W2325121566 hasConceptScore W2325121566C71924100 @default.
- W2325121566 hasLocation W23251215661 @default.
- W2325121566 hasOpenAccess W2325121566 @default.
- W2325121566 hasPrimaryLocation W23251215661 @default.
- W2325121566 hasRelatedWork W1982501772 @default.
- W2325121566 hasRelatedWork W1997930013 @default.
- W2325121566 hasRelatedWork W2080044582 @default.
- W2325121566 isParatext "false" @default.
- W2325121566 isRetracted "false" @default.
- W2325121566 magId "2325121566" @default.
- W2325121566 workType "article" @default.