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- W2325147081 abstract "Coronary artery calcification (CAC) as assessed with calcium is the best biomarker of coronary artery disease.Dual energy x-ray provides an inexpensive, low radiation-dose alternative. A two shot system (GE Revolution-XRd) isused, raw images are processed with a custom algorithm, and a coronary calcium image (DECCI) is created, similar tothe bone image, but optimized for CAC visualization, not lung visualization. In this report, we developed a physicsbased,digital-phantom containing heart, lung, CAC, spine, ribs, pulmonary artery, and adipose elements, examinedeffects on DECCI, suggested physics-inspired algorithms to improve CAC contrast, and evaluated the correlationbetween calcium scores and a proposed DE calcium score. In simulation experiment, Beam hardening fromincreasing adipose thickness (2cm to 8cm) reduced Cg by 19% and 27% in 120kVp and 60kVp images, but only reducedCg by <7% in DECCI. If a pulmonary artery moves or pulsates with blood filling between exposures, it can give rise to asignificantly confounding PA signal in DECCI similar in amplitude to CAC. Observations suggest modifications toDECCI processing, which can further improve CAC contrast by a factor of 2 in clinical exams. The DE had thebest correlation with CT mass score among three commonly used scores. Results suggest that DE x-ray is apromising tool for imaging and scoring CAC, and there still remains opportunity for further DECCI processingimprovements." @default.
- W2325147081 created "2016-06-24" @default.
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- W2325147081 date "2016-03-31" @default.
- W2325147081 modified "2023-09-23" @default.
- W2325147081 title "Dual energy x-ray imaging and scoring of coronary calcium: physics-based digital phantom and clinical studies" @default.
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- W2325147081 doi "https://doi.org/10.1117/12.2217023" @default.
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