FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2325150155> ?p ?o ?g. }

• W2325150155 abstract "Bone marrow abnormalities have been found to play a role in the pathogenesis of rheumatoid arthritis (RA). Recent studies have also confirmed the presence of undifferentiated hematopoietic progenitor cells as well as the expression of stem cell factor in the synovial membranes in RA. The present study investigates whether RA synovial fluids contain factors that can induce differentiation of CD 14 positive/HLA-DR positive cells from undifferentiated hematopoietic cells. Synovial fluid specimens from 18 patients with RA and from 10 control patients, including patients with osteoarthritis and Behcet's disease, were studied. Human promyelocytic leukemia cell line HL 60 (5 x 10(4)/well) were cultured in the presence or absence of the synovial fluids for 5 days, after which the expression of CD 14 and HLA-DR was examined by flow cytometry. The induction of differentiation of CD 14 positive/HLA-DR positive cells or HLA-DR positive cells from HL 60 cells was significantly enhanced more in the presence of synovial fluids from RA patients than in the presence of those of control patients. However, the sera from the RA patients could not induce the differentiation of CD 14 positive/HLA-DR positive cells or HLA-DR positive cells from HL 60 cells. Most cytokines found in RA synovial fluid could not induce the differentiation of HL 60 cells. Of note, treatment of synovial fluids with hyaluronidase significantly decreased or abrogated their capacity to induce the differentiation of HLA-DR positive cells from HL 60. There was no significant difference in the concentration of hyaluronic acid in the synovial fluid between the RA patients and the control patients. These results indicate that there are factors that can induce differentiation of HLA-DR positive cells from undifferentiated hematopoietic cells in the synovial fluid of RA. The data also suggest that such differentiation factors might be related with qualitative abnormality of hyaluronic acid." @default.
• W2325150155 created "2016-06-24" @default.
• W2325150155 creator A5088519518 @default.
• W2325150155 date "2000-01-01" @default.
• W2325150155 modified "2023-09-28" @default.
• W2325150155 title "Synovial fluids from patients with rheumatoid arthritis induce the differentiation of human promyelocytic leukemia cell line HL 60." @default.
• W2325150155 cites W1542731022 @default.
• W2325150155 cites W159629284 @default.
• W2325150155 cites W1659640427 @default.
• W2325150155 cites W1968028322 @default.
• W2325150155 cites W1973306904 @default.
• W2325150155 cites W1976262436 @default.
• W2325150155 cites W1996794055 @default.
• W2325150155 cites W2000547781 @default.
• W2325150155 cites W2007088223 @default.
• W2325150155 cites W2007907893 @default.
• W2325150155 cites W2014520088 @default.
• W2325150155 cites W2028052630 @default.
• W2325150155 cites W2045590518 @default.
• W2325150155 cites W2050115710 @default.
• W2325150155 cites W2077425329 @default.
• W2325150155 cites W2082492330 @default.
• W2325150155 cites W2091444591 @default.
• W2325150155 cites W2093446277 @default.
• W2325150155 cites W2093714926 @default.
• W2325150155 cites W2097833923 @default.
• W2325150155 cites W2101429849 @default.
• W2325150155 cites W2152348310 @default.
• W2325150155 cites W2158952594 @default.
• W2325150155 cites W2171680483 @default.
• W2325150155 cites W2324020725 @default.
• W2325150155 cites W2440509111 @default.
• W2325150155 cites W91710746 @default.
• W2325150155 doi "https://doi.org/10.2177/jsci.23.103" @default.
• W2325150155 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10863325" @default.
• W2325150155 hasPublicationYear "2000" @default.
• W2325150155 type Work @default.
• W2325150155 sameAs 2325150155 @default.
• W2325150155 citedByCount "1" @default.
• W2325150155 crossrefType "journal-article" @default.
• W2325150155 hasAuthorship W2325150155A5088519518 @default.
• W2325150155 hasBestOaLocation W23251501551 @default.
• W2325150155 hasConcept C142724271 @default.
• W2325150155 hasConcept C203014093 @default.
• W2325150155 hasConcept C204787440 @default.
• W2325150155 hasConcept C2776164576 @default.
• W2325150155 hasConcept C2776268809 @default.
• W2325150155 hasConcept C2776601000 @default.
• W2325150155 hasConcept C2777575956 @default.
• W2325150155 hasConcept C2778461978 @default.
• W2325150155 hasConcept C2781121885 @default.
• W2325150155 hasConcept C502942594 @default.
• W2325150155 hasConcept C54355233 @default.
• W2325150155 hasConcept C71924100 @default.
• W2325150155 hasConcept C81885089 @default.
• W2325150155 hasConcept C86803240 @default.
• W2325150155 hasConceptScore W2325150155C142724271 @default.
• W2325150155 hasConceptScore W2325150155C203014093 @default.
• W2325150155 hasConceptScore W2325150155C204787440 @default.
• W2325150155 hasConceptScore W2325150155C2776164576 @default.
• W2325150155 hasConceptScore W2325150155C2776268809 @default.
• W2325150155 hasConceptScore W2325150155C2776601000 @default.
• W2325150155 hasConceptScore W2325150155C2777575956 @default.
• W2325150155 hasConceptScore W2325150155C2778461978 @default.
• W2325150155 hasConceptScore W2325150155C2781121885 @default.
• W2325150155 hasConceptScore W2325150155C502942594 @default.
• W2325150155 hasConceptScore W2325150155C54355233 @default.
• W2325150155 hasConceptScore W2325150155C71924100 @default.
• W2325150155 hasConceptScore W2325150155C81885089 @default.
• W2325150155 hasConceptScore W2325150155C86803240 @default.
• W2325150155 hasLocation W23251501551 @default.
• W2325150155 hasLocation W23251501552 @default.
• W2325150155 hasOpenAccess W2325150155 @default.
• W2325150155 hasPrimaryLocation W23251501551 @default.
• W2325150155 hasRelatedWork W183352022 @default.
• W2325150155 hasRelatedWork W1968051717 @default.
• W2325150155 hasRelatedWork W2039067691 @default.
• W2325150155 hasRelatedWork W2088060471 @default.
• W2325150155 hasRelatedWork W2161633444 @default.
• W2325150155 hasRelatedWork W2185541440 @default.
• W2325150155 hasRelatedWork W2257461624 @default.
• W2325150155 hasRelatedWork W2367202190 @default.
• W2325150155 hasRelatedWork W2421165413 @default.
• W2325150155 hasRelatedWork W2530948814 @default.
• W2325150155 hasRelatedWork W2754336966 @default.
• W2325150155 hasRelatedWork W2945189105 @default.
• W2325150155 hasRelatedWork W3031208479 @default.
• W2325150155 hasRelatedWork W1590726503 @default.
• W2325150155 hasRelatedWork W2782563509 @default.
• W2325150155 hasRelatedWork W2816593428 @default.
• W2325150155 hasRelatedWork W2866415782 @default.
• W2325150155 hasRelatedWork W2888240036 @default.
• W2325150155 hasRelatedWork W3031046102 @default.
• W2325150155 hasRelatedWork W3032744727 @default.
• W2325150155 isParatext "false" @default.
• W2325150155 isRetracted "false" @default.
• W2325150155 magId "2325150155" @default.
• W2325150155 workType "article" @default.