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- W2325190038 abstract "S-29C1-5 Background/Aims: Indigenous communities in the Arctic are at high risk of exposure to persistent organic pollutants (POPs) and metals, which increases the risk of adverse reproductive health effects (AMAP 2009). The objective of the study was assessment of the PTS blood levels in the coastal and inland Chukotka and in Commander Islands, and evaluation of the pregnancy outcomes in connection with maternal exposure in Chukotka. Methods: In all, 126 maternal blood samples from coastal and inland Chukotka, 92 blood samples from population of both genders from Chukotka and 89 blood samples from population of Commander Islands (all collected in 2001–2003) were analyzed for PCBs, DDTs, HCHs, HCB, oxychlordane, t-nonachlor, mirex, toxaphenes, mercury, lead, and cadmium. Data on maternal and child health were collected from the mothers' medical files, newborns' delivery records, and questionnaires of the mothers. Results: Geographically, the highest blood levels of the majority of pollutants were detected in coastal Chukotka obviously due to traditional marine mammal consumption and additional contamination of foodstuffs during storing. Concentrations of PCBs in about 70% of blood samples from pregnant women and women of reproductive age from coastal Chukotka were found exceeding the internationally recommended levels of concern and, in some cases (up to 20%), action levels. Concentrations of mercury in about 60% of blood samples from women of reproductive age from coastal Chukotka were found exceeding the level of concern. Concentrations of lead in about 35% of blood samples from women and 75% from men from coastal Chukotka, and about 60% from men from inland Chukotka were found exceeding action level. Some associations between the maternal serum concentration of selected POPs and a number of adverse reproductive effects such as premature births, low birth weight, developmental defects have been shown, in some cases statistically significant. No reliable differences of average blood levels of metals were identified between pregnancy failure women and the control group. Analysis of menstrual status anamnesis of Chukotka mothers has shown certain associations between the maternal serum concentrations of specific POPs and such parameters as age of first menses, cycle length, and bleeding duration. Conclusion: The results of the study demonstrate high levels of PTS exposure of indigenous people in Chukotka and Commander Islands, increased risk of adverse pregnancy outcomes, and the necessity of risk reduction measures substantially in coastal Chukotka." @default.
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- W2325190038 date "2011-01-01" @default.
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- W2325190038 title "The North Pacific Russian Experience: Chukotka and Commander Islands Indigenous Population Exposure to PTS and Pregnancy Outcomes" @default.
- W2325190038 doi "https://doi.org/10.1097/01.ede.0000391853.12483.2b" @default.
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