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- W2325207282 abstract "Muscle biopsy is commonly used in research. One rare complication is a hematoma that generally develops rapidly within 72h post-biopsy. PURPOSE: To report an unusual case of a late-appearing hematoma following eccentric exercise (ECC) and muscle biopsy. METHODS: 10 sedentary, healthy men (22 ± 0.7y) not taking medications/supplements participated in a kinesiology research study. Baseline strength of knee extensors and flexors (isometric and isokinetic at 60 & 180°/s) was tested followed by a unilateral knee extensor ECC (10 sets of 10 maximal effort 30°/s repetitions, 1min rest between sets). Strength was re-assessed 5min, 1, 4, and 9d post-exercise. 2d after exercise, muscle biopsies were taken from the vastus lateralis of both legs. Exercise sessions and biopsies were uneventful. Subjects were directed to limit activity for 1 wk post-biopsy. RESULTS: The case subject's isometric strength loss at 1d post-exercise was greater (45% extension, 19% flexion) than other subjects (mean±SEM= 22±6% and 4±5%, respectively). At 2d post-biopsy, his isometric strength dropped precipitously (90% extension, 40% flexion), while other subjects regained strength. Isokinetic strength loss was similar; he was otherwise asymptomatic. At 4d post-biopsy the subject spent 5-6h standing for his job. At 5d post-biopsy he experienced transient muscle cramping in the exercised leg. The next evening he reported rapidly increasing cramping, pain, and swelling (exercised leg). Upon admittance to a local hospital (6d post-biopsy, 8d post-exercise), his exercised thigh was swollen by 2.5cm with no indication of infection, fracture, or compartment syndrome. Serum creatine kinase (CK) was elevated at 5,630 U/L with no sign of renal compromise. A diagnosis of intramuscular hematoma was made. After 3d of local care, the subject was discharged. With physical therapy, he returned to normal function within 2 mo. CONCLUSIONS: The case subject exhibited profound strength loss and elevated CK suggesting exercise-induced muscle damage. Increased activity 4d post-biopsy may have further injured damaged tissue, promoting bleeding and hematoma. These data emphasize the importance of limiting activity and maintaining contact with subjects for at least a week after a muscle biopsy. Supported by the US Army Medical Research and Material Command" @default.
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- W2325207282 date "2011-05-01" @default.
- W2325207282 modified "2023-09-26" @default.
- W2325207282 title "Late-Appearing Intramuscular Hematoma after Eccentric Exercise and Muscle Biopsy: A Case Report" @default.
- W2325207282 doi "https://doi.org/10.1249/01.mss.0000401024.57857.96" @default.
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