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• W2325222489 abstract "Abstract MicroRNAs (miRNAs) have important roles in post-transcriptional regulation of gene expression. During viral infection, viruses utilize hosts to enhance their replication by altering cellular miRNAs. The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway plays crucial roles in the antiviral responses. In this study, two miRNAs (miR-9041 and miR-9850) from Macrobrachium rosenbergii were found to promote white spot syndrome virus (WSSV) replication. The up-regulation of miR-9041 or miR-9850 suppresses STAT expression in the gills of M. rosenbergii , which subsequently down-regulates the expression of its downstream dynamin ( Dnm ) genes: Dnm1 , Dnm2 , and Dnm3 . Knockdown of miR-9041 and miR-9850 restricts WSSV replication by up-regulating STAT and Dnm gene expression. The silencing of STAT , Dnm1 , Dnm2 , or Dnm3 led to an increase of the number of WSSV copies in shrimp. The injection of recombinant Dnm1, Dnm2, or Dnm3 proteins could inhibit WSSV replication in vivo . Overall, our research indicates the roles of host miRNAs in the enhancement of WSSV replication by regulating the host JAK/STAT pathway." @default.
• W2325222489 created "2016-06-24" @default.
• W2325222489 creator A5020115662 @default.
• W2325222489 creator A5049242358 @default.
• W2325222489 creator A5064281992 @default.
• W2325222489 date "2016-03-31" @default.
• W2325222489 modified "2023-10-17" @default.
• W2325222489 title "Two host microRNAs influence WSSV replication via STAT gene regulation" @default.
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• W2325222489 doi "https://doi.org/10.1038/srep23643" @default.
• W2325222489 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4814834" @default.
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• W2325222489 hasPublicationYear "2016" @default.
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