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- W2325225354 endingPage "128" @default.
- W2325225354 startingPage "119" @default.
- W2325225354 abstract "The presence of maternal and paternal homologs appears to be much more than just a doubling of genetic material. We know this because genomes have evolved elaborate mechanisms that permit homologous regions to sense and then respond to each other. One way in which homologs communicate is to come into contact and, in fact, Dipteran insects such as Drosophila excel at this task, aligning all pairs of maternal and paternal chromosomes, end-to-end, in essentially all somatic tissues throughout development. Here, we reexamine the widely held tenet that extensive somatic pairing of homologous sequences cannot occur in mammals and suggest, instead, that pairing may be a widespread and significant potential that has gone unnoticed in mammals because they expend considerable effort to prevent it. We then extend this discussion to interchromosomal interactions, in general, and speculate about the potential of nuclear organization and pairing to impact inheritance." @default.
- W2325225354 created "2016-06-24" @default.
- W2325225354 creator A5025796462 @default.
- W2325225354 creator A5057761009 @default.
- W2325225354 creator A5082199349 @default.
- W2325225354 date "2016-04-01" @default.
- W2325225354 modified "2023-09-25" @default.
- W2325225354 title "Pairing and anti-pairing: a balancing act in the diploid genome" @default.
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