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- W2325284468 abstract "This chapter describes the adaptive features found in voltage-gated sodium channels (NaVs) of prokaryotes and eukaryotes. These two families are distinct, having diverged early in evolutionary history but maintain a surprising degree of convergence in function. While prokaryotic NaVs are required for growth and motility, eukaryotic NaVs selectively conduct fast electrical currents for short- and long-range signaling across cell membranes in mammalian organs. Current interest in prokaryotic NaVs is stoked by their resolved high-resolution structures and functional features which are reminiscent of eukaryotic NaVs. In this chapter, comparisons between eukaryotic and prokaryotic NaVs are made to highlight the shared and unique aspects of ion selectivity, voltage sensitivity, and pharmacology. Examples of prokaryotic and eukaryotic NaV convergent evolution will be discussed within the context of their structural features." @default.
- W2325284468 created "2016-06-24" @default.
- W2325284468 creator A5026067446 @default.
- W2325284468 creator A5054490724 @default.
- W2325284468 date "2016-01-01" @default.
- W2325284468 modified "2023-09-25" @default.
- W2325284468 title "Biophysical Adaptations of Prokaryotic Voltage-Gated Sodium Channels" @default.
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- W2325284468 doi "https://doi.org/10.1016/bs.ctm.2015.12.003" @default.
- W2325284468 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27586280" @default.
- W2325284468 hasPublicationYear "2016" @default.
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