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• W2325353688 endingPage "e1004678" @default.
• W2325353688 startingPage "e1004678" @default.
• W2325353688 abstract "Combatting infectious disease is a critical global health concern and involves tackling both emerging infectious agents and newly–drug resistant strains of previously curable pathogens. The widespread and inappropriate use of antimicrobial agents has increased the frequency of resistance among human pathogens, including bacteria, fungi, and protozoan parasites, and threatened to undermine the efficacy of all existing antimicrobial drugs [1]. Whereas lethal doses of antimicrobials may select for preexisting resistant microbes, there is increasing interest in uncovering the cellular consequences of sublethal antimicrobial exposure on the development of antimicrobial resistance. There are numerous circumstances under which microbial organisms are exposed to low doses of antimicrobials, including in patients, in livestock animals, and in the environment [1–3]. Sublethal antimicrobial exposure can trigger DNA damage and genomic instability across the diversity of microbial pathogens, including bacterial and fungal species.Here we investigate general mechanisms by which antimicrobials can damage microbial DNA. We also explore downstream cellular responses to DNA damage, including DNA repair. We will look at specific examples by which antimicrobial treatment, through DNA damage and cellular responses, can induce genetic perturbations ranging from small nucleotide mutationsto gross chromosomal rearrangements [1,4]. Overall, this review aims to explore genomic pressure exerted on bacterial and fungal pathogens by antimicrobial treatment, and implications for antimicrobial resistance." @default.
• W2325353688 created "2016-06-24" @default.
• W2325353688 creator A5085487243 @default.
• W2325353688 date "2015-03-26" @default.
• W2325353688 modified "2023-10-14" @default.
• W2325353688 title "Antimicrobial-Induced DNA Damage and Genomic Instability in Microbial Pathogens" @default.
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• W2325353688 doi "https://doi.org/10.1371/journal.ppat.1004678" @default.
• W2325353688 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4374783" @default.
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• W2325353688 hasPublicationYear "2015" @default.
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