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- W2325415086 abstract "Pituitary tumors are the third most common intracranial neoplasms. Treatment for pituitary tumors involves surgery, radiation therapy, hormone regulation and chemotherapy. However, it remains challenging to treat pituitary tumors that are recurrent, aggressive, or resistant to conventional treatments. Over the last several years, checkpoint blockade immunotherapy approaches targeting the PD-1/PD-L1 axis have shown tremendous promise in treating a range of malignancies, and durable objective responses have been observed in these settings. The Programmed death ligand 1 (PD-L1, also known as B7-H1 and CD274) plays a major role in suppressing T cell responses in the immune system but has also emerged as a key biomarker whose expression predicts favorable responses to anti-PD-1/PD-L1 therapies. . We therefore explored the possibility that PD-L1 was overexpressed in pituitary tumors and potentially represent a biomarker for patients with particularly refractory tumors who may be suitable candidates for immunotherapeutic approaches. To determine the PD-L1 mediated tumor immune status of pituitary tumors and its correlation with tumor classification, PD-L1 expression in ninety-two pituitary tumors were evaluated by RNAscope in situ hybridization and immunohistochemistry for RNA and protein levels, respectively. Both PD-L1 RNA and protein expression were significantly increased in non-functioning and functioning pituitary tumors, especially in hGH- secreting tumors, compared with normal pituitary tisssue. PD-L1 level was observed in both slowly and actively-dividing tumors, with high expression in tumors MIB less than 3 and over 3. In addition to its enhanced expression in typical pituitary tumors, PD-L1 was also dramatically increased in the atypical type which is more aggressive and invasive. Moreover, PD-L1 was not only expressed highly in primary tumors but also increased significantly in recurrent pituitary tumors. Together, these findings demonstrated significantly elevated PD-L1 expression in a broad range of human pituitary tumors irrespective of tumor hormone secretion, mitosis, aggressiveness level, or recurrence status. These data therefore raise the possibility that patients with high pituitary PD-L1 expression may represent candidates for anti-PD-1/PD-L1 therapy in surgically-refractory settings." @default.
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- W2325415086 date "2016-03-03" @default.
- W2325415086 modified "2023-10-16" @default.
- W2325415086 title "Elevated Expression of Programmed Death Ligand1 in Human Pituitary Tumors" @default.
- W2325415086 doi "https://doi.org/10.1055/s-0036-1580024" @default.
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