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- W2325488889 abstract "Title: Pyrazole Carboxamide Compounds, Compositions and Methods of Use Patent Application Number: WO 2014/023258 Al Publication date: 13 February 2014 Priority Application: US 61/682,063 Priority date: 10 August 2012 US 61/764,434 13 February 2013 US 61/764,930 14 February 2013 Inventors: Brookfield, F.; Burch, J.; Goldsmith, R. A.; Hu, B.; Lau, K. H. L.; Mackinnon, C. H.; Ortwine, D. F.; Pei, Z.; Wu, G.; Yuen, P.-W.; Zhang, Y. Assignee Company: F. Hoffmann-La Roche AG, Grenzacherstrasse, 124, CH-4070 Basel (CH) (for all designated States except US) Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, USA (for US only) Disease Area: Asthma and immunological or inflammatory disorders mediated by ITK kinase Biological Target: Inhibition of ITK kinase Summary: The invention in this patent application relates to pyrazole carboxamide derivatives represented generally by formula (I) which are inhibitors of ITK kinase. The compounds may potentially treat immunological or inflammatory disorders and other diseases responsive to the inhibition of ITK kinase. Interleukin-2-inducible T-cell kinase (ITK) belongs to the Tec family kinases, and it is expressed in T cells, NKT cells, NK cells, and mast cells. Activated ITK kinase mediates T cell receptor (TCR) signals through the phosphorylation and activation of phospholipase C-g (PLCg). Studies show that ITK knockout mice exhibit reduced lung inflammation, mucus production, and airway hyperreactivity in allergic asthma models. The studies also indicated that the kinase activity of ITK is necessary for asthma pathology. Additionally, ITK is found to be expressed at high levels in peripheral blood T cells of human patients with immunological and inflammatory disorders such as atopic dermatitis. Thus, inhibition of ITK kinase presents a viable therapeutic target to potentially treat the immunological or inflammatory disorders mediated by the activity of this kinase." @default.
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- W2325488889 date "2014-05-08" @default.
- W2325488889 modified "2023-09-24" @default.
- W2325488889 title "Treatment of Immunological or Inflammatory Disorders with ITK Kinase Inhibitors." @default.
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- W2325488889 doi "https://doi.org/10.1021/ml5000838" @default.
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