Matches in SemOpenAlex for { <https://semopenalex.org/work/W2325550203> ?p ?o ?g. }
- W2325550203 abstract "Uveitis is one of the major diagnostic criteria of Behçet's disease (BD), a chronic systemic inflammatory pathology with an uncertain etiology. Since uveitis is more frequent in male patients, we assessed the level and the effect of sex hormones on inflammatory responses during BD. Peripheral blood was taken from 19 patients with BD and 20 healthy subjects. Estradiol, testosterone and cortisol were measured in plasma by ELISA. Circulating mononuclear cells (PBMC) were obtained on gradient density and cultured with or without the three hormones for 24h at 37 ̊C. IL-12 and nitric oxide (NO) were measured in vivo and ex vivo by ELISA and a modified Griess method, respectively. We confirmed the significantly higher in vivo and in vitro levels of NO and IL-12 in BD in comparison to controls (P<0.05). We also found that circulating cortisol was lower in BD while sex hormones did not show any significant difference between the groups (P>0.05). In vitro, NO was reduced by estradiol and cortisol and increased by testosterone in both sexes. In contrast, while IL-12 production showed the same production profile as NO in women, estradiol and cortisol failed to reduce IL-12 levels in men. Our results may explain in part the differences observed between men and women in disease clinical expression. In fact, male patients seem to have defective IL-12 down-regulation by estradiol and cortisol that increases Th1 immune responses. This may be implicated in the severe expression of BD in men." @default.
- W2325550203 created "2016-06-24" @default.
- W2325550203 creator A5001959606 @default.
- W2325550203 creator A5010654772 @default.
- W2325550203 creator A5015354133 @default.
- W2325550203 creator A5073369675 @default.
- W2325550203 creator A5074110142 @default.
- W2325550203 creator A5079059504 @default.
- W2325550203 creator A5080437149 @default.
- W2325550203 date "2016-04-01" @default.
- W2325550203 modified "2023-09-26" @default.
- W2325550203 title "Influence des hormones stéroïdes sur la production de deux marqueurs inflammatoires, l’IL-12 et le monoxyde d’azote, au cours de la maladie de Behçet" @default.
- W2325550203 cites W1481844387 @default.
- W2325550203 cites W1714360375 @default.
- W2325550203 cites W181403444 @default.
- W2325550203 cites W1942013076 @default.
- W2325550203 cites W1968000725 @default.
- W2325550203 cites W1968380752 @default.
- W2325550203 cites W1972240373 @default.
- W2325550203 cites W1976008242 @default.
- W2325550203 cites W1976256751 @default.
- W2325550203 cites W1980440962 @default.
- W2325550203 cites W1986178220 @default.
- W2325550203 cites W1986645091 @default.
- W2325550203 cites W1987069221 @default.
- W2325550203 cites W1991417879 @default.
- W2325550203 cites W1995357381 @default.
- W2325550203 cites W2005017332 @default.
- W2325550203 cites W2010715367 @default.
- W2325550203 cites W2023381855 @default.
- W2325550203 cites W2033734245 @default.
- W2325550203 cites W2045850959 @default.
- W2325550203 cites W2046652062 @default.
- W2325550203 cites W2048831889 @default.
- W2325550203 cites W2049105058 @default.
- W2325550203 cites W2052250687 @default.
- W2325550203 cites W2053451937 @default.
- W2325550203 cites W2060116667 @default.
- W2325550203 cites W2064774270 @default.
- W2325550203 cites W2074892708 @default.
- W2325550203 cites W2075103099 @default.
- W2325550203 cites W2084099064 @default.
- W2325550203 cites W2089283421 @default.
- W2325550203 cites W2093065213 @default.
- W2325550203 cites W2095319273 @default.
- W2325550203 cites W2097107871 @default.
- W2325550203 cites W2098051272 @default.
- W2325550203 cites W2106103506 @default.
- W2325550203 cites W2108934436 @default.
- W2325550203 cites W2128241559 @default.
- W2325550203 cites W2128301134 @default.
- W2325550203 cites W2132459682 @default.
- W2325550203 cites W2143241373 @default.
- W2325550203 cites W2156796253 @default.
- W2325550203 cites W2163655430 @default.
- W2325550203 cites W2167900168 @default.
- W2325550203 cites W2172212696 @default.
- W2325550203 cites W2316772 @default.
- W2325550203 cites W2338635178 @default.
- W2325550203 cites W2473433727 @default.
- W2325550203 cites W2614940751 @default.
- W2325550203 doi "https://doi.org/10.1016/j.jfo.2015.11.010" @default.
- W2325550203 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27021132" @default.
- W2325550203 hasPublicationYear "2016" @default.
- W2325550203 type Work @default.
- W2325550203 sameAs 2325550203 @default.
- W2325550203 citedByCount "4" @default.
- W2325550203 countsByYear W23255502032017 @default.
- W2325550203 countsByYear W23255502032018 @default.
- W2325550203 countsByYear W23255502032019 @default.
- W2325550203 countsByYear W23255502032020 @default.
- W2325550203 crossrefType "journal-article" @default.
- W2325550203 hasAuthorship W2325550203A5001959606 @default.
- W2325550203 hasAuthorship W2325550203A5010654772 @default.
- W2325550203 hasAuthorship W2325550203A5015354133 @default.
- W2325550203 hasAuthorship W2325550203A5073369675 @default.
- W2325550203 hasAuthorship W2325550203A5074110142 @default.
- W2325550203 hasAuthorship W2325550203A5079059504 @default.
- W2325550203 hasAuthorship W2325550203A5080437149 @default.
- W2325550203 hasConcept C126322002 @default.
- W2325550203 hasConcept C134018914 @default.
- W2325550203 hasConcept C137061746 @default.
- W2325550203 hasConcept C150903083 @default.
- W2325550203 hasConcept C202751555 @default.
- W2325550203 hasConcept C203014093 @default.
- W2325550203 hasConcept C207001950 @default.
- W2325550203 hasConcept C26291073 @default.
- W2325550203 hasConcept C2776194053 @default.
- W2325550203 hasConcept C2779279991 @default.
- W2325550203 hasConcept C519581460 @default.
- W2325550203 hasConcept C55493867 @default.
- W2325550203 hasConcept C71315377 @default.
- W2325550203 hasConcept C71924100 @default.
- W2325550203 hasConcept C86803240 @default.
- W2325550203 hasConcept C8891405 @default.
- W2325550203 hasConceptScore W2325550203C126322002 @default.
- W2325550203 hasConceptScore W2325550203C134018914 @default.
- W2325550203 hasConceptScore W2325550203C137061746 @default.
- W2325550203 hasConceptScore W2325550203C150903083 @default.
- W2325550203 hasConceptScore W2325550203C202751555 @default.