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- W2325642794 startingPage "7405" @default.
- W2325642794 abstract "Histone tails are highly flexible N- or C-terminal protrusions of histone proteins which facilitate the compaction of DNA into dense superstructures known as chromatin. On a molecular scale histone tails are polyelectrolytes with high degree of conformational disorder which allows them to function as biomolecular “switches”, regulating various genetic processes. Unfortunately, their intrinsically disordered nature creates obstacles for comprehensive experimental investigation of both the structural and dynamical aspects of histone tails, because of which their conformational behaviors are still not well understood. In this work we have carried out ∼3 microsecond long all atom replica exchange molecular dynamics (REMD) simulations for each of four histone tails, H4, H3, H2B, and H2A, and probed their intrinsic conformational preferences. Our subsequent free energy landscape analysis demonstrated that most tails are not fully disordered, but show distinct conformational organization, containing specific flickering secondary structural elements. In particular, H4 forms β-hairpins, H3 and H2B adopt α-helical elements, while H2A is fully disordered. We rationalized observed patterns of conformational dynamics of various histone tails using ideas from physics of polyelectrolytes and disordered systems. We also discovered an intriguing re-entrant contraction–expansion of the tails upon heating, which is caused by subtle interplay between ionic screening and chain entropy." @default.
- W2325642794 created "2016-06-24" @default.
- W2325642794 creator A5008042705 @default.
- W2325642794 creator A5009982949 @default.
- W2325642794 date "2011-04-25" @default.
- W2325642794 modified "2023-10-17" @default.
- W2325642794 title "Energy Landscape Analyses of Disordered Histone Tails Reveal Special Organization of Their Conformational Dynamics" @default.
- W2325642794 cites W1526251404 @default.
- W2325642794 cites W1964079542 @default.
- W2325642794 cites W1965361199 @default.
- W2325642794 cites W1965672865 @default.
- W2325642794 cites W1967591301 @default.
- W2325642794 cites W1969256423 @default.
- W2325642794 cites W1969263578 @default.
- W2325642794 cites W1969715908 @default.
- W2325642794 cites W1970434234 @default.
- W2325642794 cites W1970959049 @default.
- W2325642794 cites W1975769486 @default.
- W2325642794 cites W1978908092 @default.
- W2325642794 cites W1980146626 @default.
- W2325642794 cites W1983459461 @default.
- W2325642794 cites W1985070997 @default.
- W2325642794 cites W1986411314 @default.
- W2325642794 cites W1987726601 @default.
- W2325642794 cites W1990279360 @default.
- W2325642794 cites W1992656190 @default.
- W2325642794 cites W1997970296 @default.
- W2325642794 cites W1998051622 @default.
- W2325642794 cites W2001773296 @default.
- W2325642794 cites W2002698073 @default.
- W2325642794 cites W2007888234 @default.
- W2325642794 cites W2008153594 @default.
- W2325642794 cites W2014594953 @default.
- W2325642794 cites W2015805666 @default.
- W2325642794 cites W2017117976 @default.
- W2325642794 cites W2019169996 @default.
- W2325642794 cites W2025917857 @default.
- W2325642794 cites W2027626583 @default.
- W2325642794 cites W2030207939 @default.
- W2325642794 cites W2033210496 @default.
- W2325642794 cites W2034299708 @default.
- W2325642794 cites W2037794607 @default.
- W2325642794 cites W2038066715 @default.
- W2325642794 cites W2038916674 @default.
- W2325642794 cites W2040809566 @default.
- W2325642794 cites W2041336616 @default.
- W2325642794 cites W2041669759 @default.
- W2325642794 cites W2041774584 @default.
- W2325642794 cites W2043679962 @default.
- W2325642794 cites W2045046889 @default.
- W2325642794 cites W2045936911 @default.
- W2325642794 cites W2049108972 @default.
- W2325642794 cites W2054428311 @default.
- W2325642794 cites W2054762683 @default.
- W2325642794 cites W2060491164 @default.
- W2325642794 cites W2061111901 @default.
- W2325642794 cites W2061828009 @default.
- W2325642794 cites W2064560669 @default.
- W2325642794 cites W2067926399 @default.
- W2325642794 cites W2068745847 @default.
- W2325642794 cites W2069328568 @default.
- W2325642794 cites W2071525876 @default.
- W2325642794 cites W2081250943 @default.
- W2325642794 cites W2086003265 @default.
- W2325642794 cites W2086882324 @default.
- W2325642794 cites W2087533857 @default.
- W2325642794 cites W2088431067 @default.
- W2325642794 cites W2089037468 @default.
- W2325642794 cites W2089774055 @default.
- W2325642794 cites W2089927103 @default.
- W2325642794 cites W2094795801 @default.
- W2325642794 cites W2096125044 @default.
- W2325642794 cites W2097081229 @default.
- W2325642794 cites W2097081350 @default.
- W2325642794 cites W2097891553 @default.
- W2325642794 cites W2101513897 @default.
- W2325642794 cites W2106140689 @default.
- W2325642794 cites W2108798393 @default.
- W2325642794 cites W2114358470 @default.
- W2325642794 cites W2116097904 @default.
- W2325642794 cites W2118608964 @default.
- W2325642794 cites W2119876135 @default.
- W2325642794 cites W2129695352 @default.
- W2325642794 cites W2130469852 @default.
- W2325642794 cites W2139507250 @default.
- W2325642794 cites W2140388293 @default.
- W2325642794 cites W2144288821 @default.
- W2325642794 cites W2144792857 @default.
- W2325642794 cites W2149235729 @default.
- W2325642794 cites W2158476854 @default.
- W2325642794 cites W2164270482 @default.
- W2325642794 cites W2166633156 @default.
- W2325642794 cites W2168239703 @default.
- W2325642794 cites W3098529254 @default.
- W2325642794 cites W3100565380 @default.
- W2325642794 cites W3101006260 @default.
- W2325642794 cites W4210968583 @default.
- W2325642794 cites W4239403073 @default.