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- W2325648051 abstract "Safety and tolerance studies on a newly introduced antidepressant, Org GB 94 were performed on 6 healthy male volunteers ranging in age from 23 to 40 years old. Org GB 94 was administered orally in the dose range of 10-40 mg/day. After the drug administration, there were no unusual findings with the physical and hematological examinations, liver function tests, serum-electrolytes, urea nitrogen, pancreatic function tests, urinalysis, ECG and EEG, except for a tendency for a slight decrease in blood pressure and a slight tachycardia after medicationFrom these results, the safety and tolerance in the dose range of 10-40 mg Org GB 94/day were so confirmed that we feel we have obtained enough background data to proceed with the Phase II study." @default.
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- W2325648051 date "1977-01-01" @default.
- W2325648051 modified "2023-09-27" @default.
- W2325648051 title "Phase I Study on Mianserin Hydrochloride (Org GB 94)" @default.
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- W2325648051 doi "https://doi.org/10.3999/jscpt.8.501" @default.
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