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- W2325656071 abstract "Purpose: We investigated whether the Jurkat T cell line became toxic when treated with various concentrations of FK506. We analyzed the microRNA expression patterns after the cells were stimulated with FK506 using a microRNA microarray, as well as the expression patterns of genes related to differentiation, activation, and proliferation of T cells. Methods: To investigate the effects of FK506 on microRNA expression, we purified total RNA from Jurkat cells treated with 20 μM FK506 for 72 h and analyzed the microRNA profile using an Agilent chip. Results: The results demonstrated that treatment with FK506 markedly downregulated 20 microRNAs and upregulated 20 microRNAs in a time-dependent manner. Genes downregulated by FK506 included let-7a*, miR-20a*, and miR-487a. In contrast, miR-202, miR-485-5p, and miR-518c* were gradually upregulated. Sanger Institute and DAVIS bioinformatics analyses indicated that the microRNAs regulated several transcriptomes including NFATc-related, T cell receptor/interleukin-2 signaling, and Ca2 + −calmodulin-dependent phosphatase calcineurin pathways. Conclusion: We found that FK506 is not only involved in suppressing T cell proliferation/activation by inhibiting calcineurin during Jurkat apoptosis but also affected the microRNAs that are involved in the regulation of various signal transduction pathways." @default.
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- W2325656071 date "2017-05-01" @default.
- W2325656071 modified "2023-09-26" @default.
- W2325656071 title "MicroRNA Profiling of Tacrolimus (FK506)-stimulated Jurkat Human T Lympocytes" @default.
- W2325656071 doi "https://doi.org/10.1097/01.tp.0000520394.46721.d6" @default.
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