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- W2325687592 abstract "Introduction: Antiepileptic drugs (AED) are frequently used in neurology and psychiatry. We examined the influence of gender, age, smoking habit and body weight on serum levels of carbamazepine (CBM), lamotrigine (LMT), levetiracetam (LVT), pregabalin (PRG) and valproic acid (VPA) under naturalistic conditions. Methods: Therapeutic drug monitoring (TDM) analyses from 2009 to 2010 were retrospectively evaluated by U-tests and Spearman's Rho correlations. Results: Spearman's Rho correlation between serum level and daily dose was significant in all AEDs (p < 0.001). Body weight correlated negative with the ratio CBM-Epoxid/CBM (p < 0.05). Dose-corrected LMT serum concentration correlated with age (p < 0.05) and smokers had lower dose-corrected serum levels in comparison to non-smokers (p < 0.01). Dose-corrected serum level of LVT correlated with age (p < 0.001) and was higher in females (p < 0.01) in comparison to males. PRG serum levels correlated with body weight (p = 0.001) and with age (p < 0.001). A significant correlation between dose-corrected serum level of VPA and body weight (p < 0.001) was detected. Dose-corrected VPA serum levels in smokers were lower than in non-smokers (p < 0.001) and in females higher than in males (p < 0.01). Discussion: Gender, age, smoking habit and body weight can influence the serum concentration of AEDs and therefore TDM is recommended to facilitate optimal dosing in an individual patient." @default.
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- W2325687592 date "2013-09-13" @default.
- W2325687592 modified "2023-10-16" @default.
- W2325687592 title "The influence of gender, age, smoking habit and body weight on serum levels of antiepileptic drugs under naturalistic conditions" @default.
- W2325687592 doi "https://doi.org/10.1055/s-0033-1353321" @default.
- W2325687592 hasPublicationYear "2013" @default.
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