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• W2325731811 abstract "A stochastic model of aging is developed in terms of accumulation and expression of intracellular lesions caused by environment or intrinsic genetic program. In contrast to the commonly used Gompertz-Makeham approach to the parametric analysis of mortality data, the model yields a hazard function that is bounded from above. For testing the model in experiments aimed at studying animal longevity, a Kolmogorov-type statistical test is presented with regard to the hypothesis involving unknown parameters. Examples concerning longevity of intact animals of two different species, as well as the effect of a prolonged irradiation at a low dose rate, are given to illustrate the model application and goodness-of-fit testing. The results of the analysis of published data show that the rate of lesion formation is not sustained at a constant level throughout life, though in some cases its variations with age can be considered negligible." @default.
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• W2325731811 date "1995-03-01" @default.
• W2325731811 modified "2023-09-25" @default.
• W2325731811 title "Testing a Model of Aging in Animal Experiments" @default.
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• W2325731811 doi "https://doi.org/10.2307/2533345" @default.
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