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- W2325735899 abstract "<h3>Objectives</h3> To generate a prognostic classification method for Amyotrophic Lateral Sclerosis (ALS) from a prognostic model built using clinical variables from a population register. <h3>Materials and Methods</h3> We carried out a retrospective multivariate analysis of 713 patients with ALS over a 20 year period from the South-East England Amyotrophic Lateral Sclerosis (SEALS) population register. Patients were randomly allocated to ‘discovery’ or ‘test’ cohorts. A prognostic score was calculated using the discovery cohort and then used to predict survival in the test cohort. This score was used as a predictor variable in subsequent survival analyses, either as a raw value for a Cox regression or split into four prognostic categories (good, moderate, average, poor). <h3>Results</h3> A prognostic score generated from one cohort of patients predicted survival for a second cohort of patients (r<sup>2</sup>=0.72). Six variables were included in the survival model: age at onset, diagnostic delay, El Escorial category, use of riluzole, gender and site of onset. Cox regression demonstrated a strong relationship between these variables and survival (χ<sup>2</sup> 80.8, df 1, p<0.0001, n=343) in the test cohort. Kaplan-Meier analysis demonstrated a significant difference in survival between clinical categories (log rank 161.932, df 3, p<0.001). <h3>Conclusion</h3> It is possible to correctly classify patients into prognostic categories using clinical data easily available at time of diagnosis." @default.
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- W2325735899 date "2012-11-01" @default.
- W2325735899 modified "2023-09-27" @default.
- W2325735899 title "PROGNOSTIC CATEGORIES FOR AMYOTROPHIC LATERAL SCLEROSIS" @default.
- W2325735899 doi "https://doi.org/10.1136/jnnp-2012-304200a.120" @default.
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