FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2325764204> ?p ?o ?g. }

• W2325764204 endingPage "826" @default.
• W2325764204 startingPage "816" @default.
• W2325764204 abstract "Animal studies report a nephron deficit in offspring exposed to maternal diabetes, yet are limited to models of severe hyperglycaemia which do not reflect the typical clinical condition and which are associated with foetal growth restriction that may confound nephron endowment. We aimed to assess renal morphology and function in offspring of leptin receptor deficient mice (Leprdb /+) and hypothesized that exposure to impaired maternal glucose tolerance (IGT) would be detrimental to the developing kidney.Nephron endowment was assessed in offspring of C57BKS/J Leprdb /+ and +/+ mice at embryonic day (E)18 and postnatal day (PN)21 using design-based stereology. Transcutaneous measurement of renal function and total glomerular volume were assessed in 6-month-old offspring. Only +/+ offspring of Leprdb /+ dams were analysed.Compared with +/+ dams, Leprdb /+ dams had a 20% and 35% decrease in glucose tolerance prior to pregnancy and at E17.5 respectively. Offspring of IGT Leprdb /+ dams had approximately 15% fewer nephrons at E18.5 and PN21 than offspring of +/+ dams. There was no difference in offspring bodyweight. Despite normal renal function, total glomerular volume was 13% greater in 6-month-old offspring of IGT Leprdb /+ dams than in +/+ offspring.IGT throughout gestation resulted in a nephron deficit that was established early in renal development. Maternal IGT was associated with glomerular hypertrophy in adult offspring, likely a compensatory response to maintain normal renal function. Given the increasing prevalence of IGT, monitoring glucose from early in gestation may be important to prevent altered kidney morphology. Copyright © 2016 John Wiley & Sons, Ltd." @default.
• W2325764204 created "2016-06-24" @default.
• W2325764204 creator A5003628124 @default.
• W2325764204 creator A5020516344 @default.
• W2325764204 creator A5022109519 @default.
• W2325764204 creator A5023628325 @default.
• W2325764204 creator A5028816666 @default.
• W2325764204 creator A5044552554 @default.
• W2325764204 creator A5044946054 @default.
• W2325764204 creator A5058565195 @default.
• W2325764204 creator A5068548177 @default.
• W2325764204 date "2016-05-03" @default.
• W2325764204 modified "2023-10-16" @default.
• W2325764204 title "Maternal glucose intolerance reduces offspring nephron endowment and increases glomerular volume in adult offspring" @default.
• W2325764204 cites W1957713185 @default.
• W2325764204 cites W1966772525 @default.
• W2325764204 cites W1971880124 @default.
• W2325764204 cites W1983376567 @default.
• W2325764204 cites W2003277720 @default.
• W2325764204 cites W2006946978 @default.
• W2325764204 cites W2012209586 @default.
• W2325764204 cites W2016499666 @default.
• W2325764204 cites W2017734609 @default.
• W2325764204 cites W2023301525 @default.
• W2325764204 cites W2027270172 @default.
• W2325764204 cites W2029908327 @default.
• W2325764204 cites W2030444579 @default.
• W2325764204 cites W2032385561 @default.
• W2325764204 cites W2035372437 @default.
• W2325764204 cites W2036698991 @default.
• W2325764204 cites W2037485753 @default.
• W2325764204 cites W2038479789 @default.
• W2325764204 cites W2046529449 @default.
• W2325764204 cites W2049137560 @default.
• W2325764204 cites W2051441317 @default.
• W2325764204 cites W2065052477 @default.
• W2325764204 cites W2073928485 @default.
• W2325764204 cites W2077581120 @default.
• W2325764204 cites W2089174116 @default.
• W2325764204 cites W2090063811 @default.
• W2325764204 cites W2099257459 @default.
• W2325764204 cites W2105723400 @default.
• W2325764204 cites W2110354633 @default.
• W2325764204 cites W2122628882 @default.
• W2325764204 cites W2126878764 @default.
• W2325764204 cites W2128257551 @default.
• W2325764204 cites W2132728896 @default.
• W2325764204 cites W2134284126 @default.
• W2325764204 cites W2134561732 @default.
• W2325764204 cites W2144027819 @default.
• W2325764204 cites W2150715319 @default.
• W2325764204 cites W2155180926 @default.
• W2325764204 cites W2168443858 @default.
• W2325764204 cites W2216160977 @default.
• W2325764204 cites W4240986128 @default.
• W2325764204 cites W53686672 @default.
• W2325764204 doi "https://doi.org/10.1002/dmrr.2805" @default.
• W2325764204 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27037899" @default.
• W2325764204 hasPublicationYear "2016" @default.
• W2325764204 type Work @default.
• W2325764204 sameAs 2325764204 @default.
• W2325764204 citedByCount "17" @default.
• W2325764204 countsByYear W23257642042017 @default.
• W2325764204 countsByYear W23257642042018 @default.
• W2325764204 countsByYear W23257642042019 @default.
• W2325764204 countsByYear W23257642042020 @default.
• W2325764204 countsByYear W23257642042021 @default.
• W2325764204 countsByYear W23257642042022 @default.
• W2325764204 countsByYear W23257642042023 @default.
• W2325764204 crossrefType "journal-article" @default.
• W2325764204 hasAuthorship W2325764204A5003628124 @default.
• W2325764204 hasAuthorship W2325764204A5020516344 @default.
• W2325764204 hasAuthorship W2325764204A5022109519 @default.
• W2325764204 hasAuthorship W2325764204A5023628325 @default.
• W2325764204 hasAuthorship W2325764204A5028816666 @default.
• W2325764204 hasAuthorship W2325764204A5044552554 @default.
• W2325764204 hasAuthorship W2325764204A5044946054 @default.
• W2325764204 hasAuthorship W2325764204A5058565195 @default.
• W2325764204 hasAuthorship W2325764204A5068548177 @default.
• W2325764204 hasBestOaLocation W23257642041 @default.
• W2325764204 hasConcept C112672928 @default.
• W2325764204 hasConcept C126322002 @default.
• W2325764204 hasConcept C134018914 @default.
• W2325764204 hasConcept C159641895 @default.
• W2325764204 hasConcept C2777180221 @default.
• W2325764204 hasConcept C2779234561 @default.
• W2325764204 hasConcept C2780609358 @default.
• W2325764204 hasConcept C2781231759 @default.
• W2325764204 hasConcept C46973012 @default.
• W2325764204 hasConcept C54355233 @default.
• W2325764204 hasConcept C555293320 @default.
• W2325764204 hasConcept C71924100 @default.
• W2325764204 hasConcept C86803240 @default.
• W2325764204 hasConceptScore W2325764204C112672928 @default.
• W2325764204 hasConceptScore W2325764204C126322002 @default.
• W2325764204 hasConceptScore W2325764204C134018914 @default.
• W2325764204 hasConceptScore W2325764204C159641895 @default.
• W2325764204 hasConceptScore W2325764204C2777180221 @default.

• next