Matches in SemOpenAlex for { <https://semopenalex.org/work/W2325860280> ?p ?o ?g. }
- W2325860280 endingPage "3158" @default.
- W2325860280 startingPage "3153" @default.
- W2325860280 abstract "Telomeres are guanosine-rich nucleic-acid chains that fold, in the presence of K+ ions and hemin, into the telomeric hemin/G-quadruplex structure, exhibiting horseradish peroxidase mimicking functions. The telomeric hemin/G-quadruplex structures catalyze the oxidation of thiols (e.g., l-cysteine) into disulfides (e.g., cystine). As l-cysteine stimulates the aggregation of Au nanoparticles (NPs), accompanied by absorbance changes from red (individual Au NPs) to blue (aggregated Au NPs), the process is implemented to quantitatively analyze the activity (content) of telomerase, a versatile biomarker for cancer cells. Telomerase extracted from 293T cancer cells catalyzes, in the presence of a dNTPs mixture and an appropriate primer probe, the telomerization process, leading to the generation of catalytic telomeric hemin/G-quadruplex chains that control the l-cysteine-mediated aggregation of Au NPs. The extent of aggregation is thus controlled by the concentration of telomerase. The method enabled the detection of telomerase with a detection limit of 27 cells/μL. The spectral changes accompanying the aggregation of Au NPs are further supported by transmission electron microscopy imaging." @default.
- W2325860280 created "2016-06-24" @default.
- W2325860280 creator A5003359226 @default.
- W2325860280 creator A5007028964 @default.
- W2325860280 creator A5037842873 @default.
- W2325860280 creator A5047358866 @default.
- W2325860280 creator A5047478941 @default.
- W2325860280 date "2014-02-25" @default.
- W2325860280 modified "2023-10-09" @default.
- W2325860280 title "Analysis of Telomerase by the Telomeric Hemin/G-Quadruplex-Controlled Aggregation of Au Nanoparticles in the Presence of Cysteine" @default.
- W2325860280 cites W1496772673 @default.
- W2325860280 cites W1967044367 @default.
- W2325860280 cites W1969390742 @default.
- W2325860280 cites W1981254614 @default.
- W2325860280 cites W1999091059 @default.
- W2325860280 cites W2000971601 @default.
- W2325860280 cites W2001828972 @default.
- W2325860280 cites W2004136890 @default.
- W2325860280 cites W2010882280 @default.
- W2325860280 cites W2011109603 @default.
- W2325860280 cites W2014083889 @default.
- W2325860280 cites W2015037479 @default.
- W2325860280 cites W2023542461 @default.
- W2325860280 cites W2025176070 @default.
- W2325860280 cites W2030976397 @default.
- W2325860280 cites W2033488675 @default.
- W2325860280 cites W2040039962 @default.
- W2325860280 cites W2042996581 @default.
- W2325860280 cites W2046133147 @default.
- W2325860280 cites W2046892466 @default.
- W2325860280 cites W2056052888 @default.
- W2325860280 cites W2058067318 @default.
- W2325860280 cites W2077565465 @default.
- W2325860280 cites W2078820160 @default.
- W2325860280 cites W2086775312 @default.
- W2325860280 cites W2090064426 @default.
- W2325860280 cites W2106853492 @default.
- W2325860280 cites W2115029038 @default.
- W2325860280 cites W2137864764 @default.
- W2325860280 cites W2158180922 @default.
- W2325860280 cites W2316387723 @default.
- W2325860280 cites W2321864271 @default.
- W2325860280 cites W2322854553 @default.
- W2325860280 cites W4255240830 @default.
- W2325860280 cites W4376848414 @default.
- W2325860280 doi "https://doi.org/10.1021/ac5000152" @default.
- W2325860280 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24502233" @default.
- W2325860280 hasPublicationYear "2014" @default.
- W2325860280 type Work @default.
- W2325860280 sameAs 2325860280 @default.
- W2325860280 citedByCount "72" @default.
- W2325860280 countsByYear W23258602802014 @default.
- W2325860280 countsByYear W23258602802015 @default.
- W2325860280 countsByYear W23258602802016 @default.
- W2325860280 countsByYear W23258602802017 @default.
- W2325860280 countsByYear W23258602802018 @default.
- W2325860280 countsByYear W23258602802019 @default.
- W2325860280 countsByYear W23258602802020 @default.
- W2325860280 countsByYear W23258602802021 @default.
- W2325860280 countsByYear W23258602802022 @default.
- W2325860280 countsByYear W23258602802023 @default.
- W2325860280 crossrefType "journal-article" @default.
- W2325860280 hasAuthorship W2325860280A5003359226 @default.
- W2325860280 hasAuthorship W2325860280A5007028964 @default.
- W2325860280 hasAuthorship W2325860280A5037842873 @default.
- W2325860280 hasAuthorship W2325860280A5047358866 @default.
- W2325860280 hasAuthorship W2325860280A5047478941 @default.
- W2325860280 hasConcept C104317684 @default.
- W2325860280 hasConcept C119128265 @default.
- W2325860280 hasConcept C12554922 @default.
- W2325860280 hasConcept C155672457 @default.
- W2325860280 hasConcept C171250308 @default.
- W2325860280 hasConcept C181199279 @default.
- W2325860280 hasConcept C185592680 @default.
- W2325860280 hasConcept C192562407 @default.
- W2325860280 hasConcept C21951064 @default.
- W2325860280 hasConcept C24107716 @default.
- W2325860280 hasConcept C2776217839 @default.
- W2325860280 hasConcept C2777723881 @default.
- W2325860280 hasConcept C2779201268 @default.
- W2325860280 hasConcept C43617362 @default.
- W2325860280 hasConcept C552990157 @default.
- W2325860280 hasConcept C55493867 @default.
- W2325860280 hasConcept C83762044 @default.
- W2325860280 hasConcept C84211826 @default.
- W2325860280 hasConcept C86803240 @default.
- W2325860280 hasConcept C94581717 @default.
- W2325860280 hasConcept C98015330 @default.
- W2325860280 hasConceptScore W2325860280C104317684 @default.
- W2325860280 hasConceptScore W2325860280C119128265 @default.
- W2325860280 hasConceptScore W2325860280C12554922 @default.
- W2325860280 hasConceptScore W2325860280C155672457 @default.
- W2325860280 hasConceptScore W2325860280C171250308 @default.
- W2325860280 hasConceptScore W2325860280C181199279 @default.
- W2325860280 hasConceptScore W2325860280C185592680 @default.
- W2325860280 hasConceptScore W2325860280C192562407 @default.
- W2325860280 hasConceptScore W2325860280C21951064 @default.
- W2325860280 hasConceptScore W2325860280C24107716 @default.