Matches in SemOpenAlex for { <https://semopenalex.org/work/W2325873553> ?p ?o ?g. }
- W2325873553 endingPage "4045" @default.
- W2325873553 startingPage "4039" @default.
- W2325873553 abstract "Four generations of poly(amidoamine) (PAMAM) dendrimers decorated with benzenesulfonamide moieties were prepared by derivatizing the amino groups of the dendrimer with 4-carboxy-benzenesulfonamide functionalities. Compounds incorporating 4, 8, 16, and 32 sulfonamide moieties were thus obtained, which showed an increasing carbonic anhydrase (CA, EC 4.2.1.1) inhibitory action with the increase of the number of sulfamoyl groups in the dendrimer. Best inhibitory activity (in the low nanomolar–subnanomolar range) was observed for isoforms CA II and XII, involved among others in glaucoma. In an animal model of this disease, the chronic administration of such dendrimers for 5 days led to a much more efficient drop of intraocular pressure compared to the standard drug dorzolamide." @default.
- W2325873553 created "2016-06-24" @default.
- W2325873553 creator A5010742011 @default.
- W2325873553 creator A5018639093 @default.
- W2325873553 creator A5022798909 @default.
- W2325873553 creator A5027302864 @default.
- W2325873553 creator A5035013697 @default.
- W2325873553 creator A5060631228 @default.
- W2325873553 creator A5072935995 @default.
- W2325873553 creator A5083642064 @default.
- W2325873553 date "2015-04-15" @default.
- W2325873553 modified "2023-09-23" @default.
- W2325873553 title "Poly(amidoamine) Dendrimers with Carbonic Anhydrase Inhibitory Activity and Antiglaucoma Action" @default.
- W2325873553 cites W1573899446 @default.
- W2325873553 cites W1969894847 @default.
- W2325873553 cites W1970977423 @default.
- W2325873553 cites W1972547175 @default.
- W2325873553 cites W1975493568 @default.
- W2325873553 cites W1978763981 @default.
- W2325873553 cites W1982970232 @default.
- W2325873553 cites W1983105288 @default.
- W2325873553 cites W1983964958 @default.
- W2325873553 cites W2002483066 @default.
- W2325873553 cites W2002584091 @default.
- W2325873553 cites W2006682004 @default.
- W2325873553 cites W2007519168 @default.
- W2325873553 cites W2010314514 @default.
- W2325873553 cites W2011974303 @default.
- W2325873553 cites W2022189687 @default.
- W2325873553 cites W2023858126 @default.
- W2325873553 cites W2025322665 @default.
- W2325873553 cites W2025766128 @default.
- W2325873553 cites W2034233153 @default.
- W2325873553 cites W2046517307 @default.
- W2325873553 cites W2047178318 @default.
- W2325873553 cites W2051349300 @default.
- W2325873553 cites W2055876104 @default.
- W2325873553 cites W2058490945 @default.
- W2325873553 cites W2060279237 @default.
- W2325873553 cites W2066665206 @default.
- W2325873553 cites W2067031531 @default.
- W2325873553 cites W2072952339 @default.
- W2325873553 cites W2073439757 @default.
- W2325873553 cites W2077687384 @default.
- W2325873553 cites W2083400438 @default.
- W2325873553 cites W2092344988 @default.
- W2325873553 cites W2096304845 @default.
- W2325873553 cites W2096769771 @default.
- W2325873553 cites W2097819925 @default.
- W2325873553 cites W2099116299 @default.
- W2325873553 cites W2099248609 @default.
- W2325873553 cites W2128102076 @default.
- W2325873553 cites W2138946735 @default.
- W2325873553 cites W2144770348 @default.
- W2325873553 cites W2150627175 @default.
- W2325873553 cites W2164050991 @default.
- W2325873553 cites W2165423396 @default.
- W2325873553 cites W2168206768 @default.
- W2325873553 cites W2169128564 @default.
- W2325873553 cites W2169876508 @default.
- W2325873553 cites W2329849793 @default.
- W2325873553 cites W2409029369 @default.
- W2325873553 doi "https://doi.org/10.1021/acs.jmedchem.5b00383" @default.
- W2325873553 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25849626" @default.
- W2325873553 hasPublicationYear "2015" @default.
- W2325873553 type Work @default.
- W2325873553 sameAs 2325873553 @default.
- W2325873553 citedByCount "29" @default.
- W2325873553 countsByYear W23258735532015 @default.
- W2325873553 countsByYear W23258735532016 @default.
- W2325873553 countsByYear W23258735532017 @default.
- W2325873553 countsByYear W23258735532018 @default.
- W2325873553 countsByYear W23258735532019 @default.
- W2325873553 countsByYear W23258735532020 @default.
- W2325873553 countsByYear W23258735532021 @default.
- W2325873553 countsByYear W23258735532022 @default.
- W2325873553 countsByYear W23258735532023 @default.
- W2325873553 crossrefType "journal-article" @default.
- W2325873553 hasAuthorship W2325873553A5010742011 @default.
- W2325873553 hasAuthorship W2325873553A5018639093 @default.
- W2325873553 hasAuthorship W2325873553A5022798909 @default.
- W2325873553 hasAuthorship W2325873553A5027302864 @default.
- W2325873553 hasAuthorship W2325873553A5035013697 @default.
- W2325873553 hasAuthorship W2325873553A5060631228 @default.
- W2325873553 hasAuthorship W2325873553A5072935995 @default.
- W2325873553 hasAuthorship W2325873553A5083642064 @default.
- W2325873553 hasConcept C118487528 @default.
- W2325873553 hasConcept C169760540 @default.
- W2325873553 hasConcept C17077164 @default.
- W2325873553 hasConcept C181199279 @default.
- W2325873553 hasConcept C185592680 @default.
- W2325873553 hasConcept C2775914622 @default.
- W2325873553 hasConcept C2776727336 @default.
- W2325873553 hasConcept C2778073030 @default.
- W2325873553 hasConcept C2778527774 @default.
- W2325873553 hasConcept C2778667255 @default.
- W2325873553 hasConcept C2779158978 @default.
- W2325873553 hasConcept C2780416268 @default.