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- W2325874252 abstract "Recently, CHA2DS2-VASc score has been recommended for patients with non-valvular atrial fibrillation (NVAF) to predict the cardioembolic stroke instead of CHADS2 score. Although 1 point is assigned for female gender, it remains unclear why female patients with NVAF are susceptible to cardioembolic stroke. The purpose of this study was to investigate the association between female gender and cardioembolic risk using echocardiographic parameters in patients with NVAF. Transthoracic and transesophageal echocardiography were performed in 206 acute ischemic stroke patients with NVAF and 142 patients with paroxysmal NVAF. We divided study patients into 3 groups based on CHA2DS2-VASc score excluding sex category (score 0-1, 2-3, and 4-8). Female patients had significantly larger left atrial volume index (LAVI) than males in each group (Figure A). Patients with left atrial appendage (LAA) thrombi and/or spontaneous echo contrast (SEC) had a significantly higher LAVI compared to those without them in each group. Female patients showed a greater prevalence of LAA thrombi/SEC than males in only score 0-1 group. Patients with LAA thrombi/SEC in score 0-1 group were older and more female, and had higher LAVI compared to those without them. Multivariate logistic regression analysis revealed that LAVI but not female gender was an independent predictor of LAA thrombi/SEC. When assigning 1 point for high LAVI (≥33 ml/m2), CHADS2 score combined with LAVI more successfully risk stratified patients with NVAF than CHA2DS2-VASc score (Figure B). In conclusion, LA enlargement was strongly associated with LAA thrombi/SEC compared to female gender. It was suggested that female patients with NVAF are susceptible to cardioembolic stroke because of their left atrial enlargement." @default.
- W2325874252 created "2016-06-24" @default.
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- W2325874252 date "2013-08-02" @default.
- W2325874252 modified "2023-09-25" @default.
- W2325874252 title "Female patients with non-valvular atrial fibrillation are susceptible to cardioembolic stroke because of their left atrial enlargement" @default.
- W2325874252 doi "https://doi.org/10.1093/eurheartj/eht307.p398" @default.
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