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• W2325879723 abstract "ABSTRACT Vibrio cholerae causes human infection through ingestion of contaminated food and water, leading to the devastating diarrheal disease cholera. V. cholerae forms matrix-encased aggregates, known as biofilms, in the native aquatic environment. While the formation of V. cholerae biofilms has been well studied, little is known about the dispersal from biofilms, particularly upon entry into the host. In this study, we found that the exposure of mature biofilms to physiologic levels of the bile salt taurocholate, a host signal for the virulence gene induction of V. cholerae , induces an increase in the number of detached cells with a concomitant decrease in biofilm mass. Scanning electron microscopy micrographs of biofilms exposed to taurocholate revealed an altered, perhaps degraded, appearance of the biofilm matrix. The inhibition of protein synthesis did not alter rates of detachment, suggesting that V. cholerae undergoes a passive dispersal. Cell-free media from taurocholate-exposed biofilms contains a larger amount of free polysaccharide, suggesting an abiotic degradation of biofilm matrix by taurocholate. Furthermore, we found that V. cholerae is only able to induce virulence in response to taurocholate after exit from the biofilm. Thus, we propose a model in which V. cholerae ingested as a biofilm has coopted the host-derived bile salt signal to detach from the biofilm and go on to activate virulence." @default.
• W2325879723 created "2016-06-24" @default.
• W2325879723 creator A5003830258 @default.
• W2325879723 creator A5014197591 @default.
• W2325879723 date "2015-01-01" @default.
• W2325879723 modified "2023-09-26" @default.
• W2325879723 title "Host Intestinal Signal-Promoted Biofilm Dispersal Induces Vibrio cholerae Colonization" @default.
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• W2325879723 doi "https://doi.org/10.1128/iai.02617-14" @default.
• W2325879723 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4288906" @default.
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• W2325879723 hasPublicationYear "2015" @default.
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